3IXE

Structural basis of competition between PINCH1 and PINCH2 for binding to the ankyrin repeat domain of integrin-linked kinase

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Integrin-linked protein kinase	polymer	179	20256.9	1	UniProt (Q13418) Pfam (PF12796)	Homo sapiens (human)	ILK-1, ILK-2, 59 kDa serine/threonine-protein kinase, p59ILK
2	B (B)	LIM and senescent cell antigen-like-containing domain protein 2	polymer	72	8477.5	1	UniProt (Q7Z4I7) Pfam (PF00412)	Homo sapiens (human)	Particularly interesting new Cys-His protein 2, PINCH-2, LIM-like protein 2
3	C, D (B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
4	E, F (A, B)	water	water		18.0	369	Chemie (HOH)

Sequence modifications

A: 1 - 174 (UniProt: Q13418)

PDB	External Database	Details
Gly -4	-	expression tag
Ser -3	-	expression tag
Pro -2	-	expression tag
Glu -1	-	expression tag
Phe 0	-	expression tag

B: 6 - 68 (UniProt: Q7Z4I7)

PDB	External Database	Details
Ser -3	-	expression tag
Glu -2	-	expression tag
Asn -1	-	expression tag
Leu 0	-	expression tag
Tyr 1	-	expression tag
Phe 2	-	expression tag
Gln 3	-	expression tag
Gly 4	-	expression tag
Ser 5	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	28734.3
Non-Polymers*	Number of molecules	2
	Total formula weight	130.8
All*	Total formula weight	28865.2

*Water molecules are not included.