3IXE
Structural basis of competition between PINCH1 and PINCH2 for binding to the ankyrin repeat domain of integrin-linked kinase
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 301 |
| Chain | Residue |
| B | CYS10 |
| B | CYS13 |
| B | HIS32 |
| B | CYS35 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 302 |
| Chain | Residue |
| B | CYS38 |
| B | CYS41 |
| B | CYS59 |
| B | ASP62 |
Functional Information from PROSITE/UniProt
| site_id | PS00478 |
| Number of Residues | 36 |
| Details | LIM_DOMAIN_1 LIM zinc-binding domain signature. CqrCqarfspaerivnsngel....YHehCfvCaqCfrpF |
| Chain | Residue | Details |
| B | CYS10-PHE45 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 28 |
| Details | Repeat: {"description":"ANK 1","evidences":[{"source":"PubMed","id":"19074270","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 32 |
| Details | Repeat: {"description":"ANK 2","evidences":[{"source":"PubMed","id":"19074270","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 32 |
| Details | Repeat: {"description":"ANK 3","evidences":[{"source":"PubMed","id":"19074270","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 32 |
| Details | Repeat: {"description":"ANK 4","evidences":[{"source":"PubMed","id":"19074270","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 106 |
| Details | Region: {"description":"Interaction with LIMS1","evidences":[{"source":"PubMed","id":"12167643","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
