3IQV
Crystal Structure of human 14-3-3 sigma in Complex with Raf1 peptide (6mer) and stabilisator Fusicoccin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 14-3-3 protein sigma | polymer | 236 | 26558.9 | 1 | UniProt (P31947) Pfam (PF00244) | Homo sapiens (human) | Stratifin, Epithelial cell marker protein 1 |
| 2 | B (P) | 6-mer peptide from RAF proto-oncogene serine/threonine-protein kinase | polymer | 6 | 759.7 | 1 | UniProt (P04049) | C-RAF, cRaf, Raf-1 | |
| 3 | C (A) | FUSICOCCIN | non-polymer | 680.8 | 1 | Chemie (FSC) | |||
| 4 | D, E (A) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 5 | F, G, H, I (A) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 6 | J, K (A, P) | water | water | 18.0 | 435 | Chemie (HOH) |
Sequence modifications
A: 1 - 231 (UniProt: P31947)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Ala -3 | - | expression tag |
| Met -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 27318.6 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 848.9 | |
| All* | Total formula weight | 28167.5 |
