3IJ2

Ligand-receptor structure

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, B)	Beta-nerve growth factor	polymer	230	25450.4	2	UniProt (P01139) Pfam (PF00243)	Mus musculus (mouse)	Beta-NGF
2	B, D (X, Y)	Nerve growth factor receptor (TNFR superfamily, member 16)	polymer	171	18482.3	2	UniProt (P07174) Pfam (PF00020)	Rattus norvegicus (rat)

Sequence modifications

A, B: -102 - 120 (UniProt: P01139)

PDB	External Database	Details
Ala -72	Arg 159	engineered mutation
Ala -71	Arg 160	engineered mutation
Ala -42	Lys 189	engineered mutation
Ala -41	Arg 190	engineered mutation
Ala -1	Lys 230	engineered mutation
Ala 0	Arg 231	engineered mutation
Ala 118	Arg 349	engineered mutation
Ala 119	Arg 350	engineered mutation
His 121	-	expression tag
His 122	-	expression tag
His 123	-	expression tag
His 124	-	expression tag
His 125	-	expression tag
His 126	-	expression tag
His 127	-	expression tag

X, Y: 1 - 161 (UniProt: P07174)

PDB	External Database	Details
Ala -2	-	expression tag
Asp -1	-	expression tag
Pro 0	-	expression tag
Asp 32	Asn 64	engineered mutation
Ser 42	Asn 74	conflict
His 162	-	expression tag
His 163	-	expression tag
His 164	-	expression tag
His 165	-	expression tag
His 166	-	expression tag
His 167	-	expression tag
His 168	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	87865.4
All*	Total formula weight	87865.4

*Water molecules are not included.