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3IJ2

Ligand-receptor structure

Functional Information from GO Data
ChainGOidnamespacecontents
A0001934biological_processpositive regulation of protein phosphorylation
A0004857molecular_functionenzyme inhibitor activity
A0005102molecular_functionsignaling receptor binding
A0005163molecular_functionnerve growth factor receptor binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005788cellular_componentendoplasmic reticulum lumen
A0007169biological_processcell surface receptor protein tyrosine kinase signaling pathway
A0007422biological_processperipheral nervous system development
A0007613biological_processmemory
A0007623biological_processcircadian rhythm
A0008021cellular_componentsynaptic vesicle
A0008083molecular_functiongrowth factor activity
A0008191molecular_functionmetalloendopeptidase inhibitor activity
A0008283biological_processcell population proliferation
A0008284biological_processpositive regulation of cell population proliferation
A0008289molecular_functionlipid binding
A0008344biological_processadult locomotory behavior
A0008625biological_processextrinsic apoptotic signaling pathway via death domain receptors
A0008656molecular_functioncysteine-type endopeptidase activator activity involved in apoptotic process
A0010628biological_processpositive regulation of gene expression
A0010976biological_processpositive regulation of neuron projection development
A0014042biological_processpositive regulation of neuron maturation
A0019233biological_processsensory perception of pain
A0021675biological_processnerve development
A0021846biological_processcell proliferation in forebrain
A0030182biological_processneuron differentiation
A0030297molecular_functiontransmembrane receptor protein tyrosine kinase activator activity
A0030307biological_processpositive regulation of cell growth
A0030414molecular_functionpeptidase inhibitor activity
A0031175biological_processneuron projection development
A0031398biological_processpositive regulation of protein ubiquitination
A0031904cellular_componentendosome lumen
A0031954biological_processpositive regulation of protein autophosphorylation
A0038177molecular_functiondeath receptor agonist activity
A0038180biological_processnerve growth factor signaling pathway
A0043069biological_processnegative regulation of programmed cell death
A0043524biological_processnegative regulation of neuron apoptotic process
A0045664biological_processregulation of neuron differentiation
A0045666biological_processpositive regulation of neuron differentiation
A0045773biological_processpositive regulation of axon extension
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046579biological_processpositive regulation of Ras protein signal transduction
A0046928biological_processregulation of neurotransmitter secretion
A0048011biological_processneurotrophin TRK receptor signaling pathway
A0048672biological_processpositive regulation of collateral sprouting
A0048812biological_processneuron projection morphogenesis
A0050804biological_processmodulation of chemical synaptic transmission
A0051279biological_processregulation of release of sequestered calcium ion into cytosol
A0051388biological_processpositive regulation of neurotrophin TRK receptor signaling pathway
A0051402biological_processneuron apoptotic process
A0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0062036biological_processsensory perception of hot stimulus
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
A2000648biological_processpositive regulation of stem cell proliferation
A2000675biological_processnegative regulation of type B pancreatic cell apoptotic process
B0001934biological_processpositive regulation of protein phosphorylation
B0004857molecular_functionenzyme inhibitor activity
B0005102molecular_functionsignaling receptor binding
B0005163molecular_functionnerve growth factor receptor binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005788cellular_componentendoplasmic reticulum lumen
B0007169biological_processcell surface receptor protein tyrosine kinase signaling pathway
B0007422biological_processperipheral nervous system development
B0007613biological_processmemory
B0007623biological_processcircadian rhythm
B0008021cellular_componentsynaptic vesicle
B0008083molecular_functiongrowth factor activity
B0008191molecular_functionmetalloendopeptidase inhibitor activity
B0008283biological_processcell population proliferation
B0008284biological_processpositive regulation of cell population proliferation
B0008289molecular_functionlipid binding
B0008344biological_processadult locomotory behavior
B0008625biological_processextrinsic apoptotic signaling pathway via death domain receptors
B0008656molecular_functioncysteine-type endopeptidase activator activity involved in apoptotic process
B0010628biological_processpositive regulation of gene expression
B0010976biological_processpositive regulation of neuron projection development
B0014042biological_processpositive regulation of neuron maturation
B0019233biological_processsensory perception of pain
B0021675biological_processnerve development
B0021846biological_processcell proliferation in forebrain
B0030182biological_processneuron differentiation
B0030297molecular_functiontransmembrane receptor protein tyrosine kinase activator activity
B0030307biological_processpositive regulation of cell growth
B0030414molecular_functionpeptidase inhibitor activity
B0031175biological_processneuron projection development
B0031398biological_processpositive regulation of protein ubiquitination
B0031904cellular_componentendosome lumen
B0031954biological_processpositive regulation of protein autophosphorylation
B0038177molecular_functiondeath receptor agonist activity
B0038180biological_processnerve growth factor signaling pathway
B0043069biological_processnegative regulation of programmed cell death
B0043524biological_processnegative regulation of neuron apoptotic process
B0045664biological_processregulation of neuron differentiation
B0045666biological_processpositive regulation of neuron differentiation
B0045773biological_processpositive regulation of axon extension
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0046579biological_processpositive regulation of Ras protein signal transduction
B0046928biological_processregulation of neurotransmitter secretion
B0048011biological_processneurotrophin TRK receptor signaling pathway
B0048672biological_processpositive regulation of collateral sprouting
B0048812biological_processneuron projection morphogenesis
B0050804biological_processmodulation of chemical synaptic transmission
B0051279biological_processregulation of release of sequestered calcium ion into cytosol
B0051388biological_processpositive regulation of neurotrophin TRK receptor signaling pathway
B0051402biological_processneuron apoptotic process
B0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B0062036biological_processsensory perception of hot stimulus
B0070374biological_processpositive regulation of ERK1 and ERK2 cascade
B0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
B2000648biological_processpositive regulation of stem cell proliferation
B2000675biological_processnegative regulation of type B pancreatic cell apoptotic process
Functional Information from PROSITE/UniProt
site_idPS00248
Number of Residues14
DetailsNGF_1 Nerve growth factor family signature. GCRGIDskhWnSyC
ChainResidueDetails
AGLY67-CYS80

site_idPS00652
Number of Residues41
DetailsTNFR_NGFR_1 TNFR/NGFR family cysteine-rich region signature. Cldsvt.Fsdvvsatep.CkpCte.Clglqsmsap..Cvead..DAVC
ChainResidueDetails
XCYS39-CYS79
XCYS79-CYS118
XCYS121-CYS160

site_idPS01186
Number of Residues16
DetailsEGF_2 EGF-like domain signature 2. CrCayGYyqdeetghC
ChainResidueDetails
XCYS79-CYS94

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsBinding site: {"description":"in other chain","evidences":[{"source":"PubMed","id":"22649032","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4EAX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues2
DetailsBinding site: {"description":"in other chain","evidences":[{"source":"PubMed","id":"26144237","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4XPJ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"22649032","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4EAX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues66
DetailsRepeat: {"description":"TNFR-Cys 1"}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues82
DetailsRepeat: {"description":"TNFR-Cys 2"}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues76
DetailsRepeat: {"description":"TNFR-Cys 3"}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues80
DetailsRepeat: {"description":"TNFR-Cys 4"}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"20036257","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3BUK","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

246031

PDB entries from 2025-12-10

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