3II0

Crystal structure of human Glutamate oxaloacetate transaminase 1 (GOT1)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Aspartate aminotransferase, cytoplasmic	polymer	422	47755.7	4	UniProt (P17174) Pfam (PF00155) In PDB	Homo sapiens (human)	Transaminase A, Glutamate oxaloacetate transaminase 1
2	A, B, C, D	PYRIDOXAL-5'-PHOSPHATE	non-polymer		247.1	4	Chemie (PLP)
3	A, B, C, D	D(-)-TARTARIC ACID	non-polymer		150.1	4	Chemie (TAR)
4	A, B, C, D	1,2-ETHANEDIOL	non-polymer		62.1	13	Chemie (EDO)
5		water	water		18.0	733	Chemie (HOH)

Sequence modifications

A, B, C, D: 14 - 412 (UniProt: P17174)

PDB	External Database	Details
Met 13	-	expression tag
Ala 413	-	expression tag
Glu 414	-	expression tag
Asn 415	-	expression tag
Leu 416	-	expression tag
Tyr 417	-	expression tag
Phe 418	-	expression tag
Gln 419	-	expression tag
Ser 420	-	expression tag
His 421	-	expression tag
His 422	-	expression tag
His 423	-	expression tag
His 424	-	expression tag
His 425	-	expression tag
His 426	-	expression tag
Asp 427	-	expression tag
Tyr 428	-	expression tag
Lys 429	-	expression tag
Asp 430	-	expression tag
Asp 431	-	expression tag
Asp 432	-	expression tag
Asp 433	-	expression tag
Lys 434	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	191022.8
Non-Polymers*	Number of molecules	21
	Total formula weight	2395.8
All*	Total formula weight	193418.6

*Water molecules are not included.