3IGC
Smallpox virus topoisomerase-DNA transition state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DNA topoisomerase 1 | polymer | 314 | 36617.4 | 1 | UniProt (P32989) Pfam (PF09266) Pfam (PF01028) | Variola virus (smallpox virus) | DNA topoisomerase I |
| 2 | B (B) | 5'-D(*GP*TP*GP*TP*CP*GP*CP*CP*CP*TP*T)-3' | polymer | 11 | 3316.2 | 1 | |||
| 3 | C (C) | 5'-D(*AP*TP*TP*CP*C)-3' | polymer | 5 | 1455.0 | 1 | |||
| 4 | D (D) | 5'-D(*CP*GP*GP*AP*AP*TP*AP*AP*GP*GP*GP*CP*GP*AP*CP*A)-3' | polymer | 16 | 4981.3 | 1 | |||
| 5 | E (A) | VANADATE ION | non-polymer | 114.9 | 1 | Chemie (VO4) | |||
| 6 | F, G, H, I (A, B, C, D) | water | water | 18.0 | 426 | Chemie (HOH) |
Sequence modifications
A: 1 - 314 (UniProt: P32989)
| PDB | External Database | Details |
|---|---|---|
| Ser 100 | Cys 100 | engineered mutation |
| Ser 211 | Cys 211 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 46369.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 114.9 | |
| All* | Total formula weight | 46484.8 |
