3IGC

Smallpox virus topoisomerase-DNA transition state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003916	molecular_function	DNA topoisomerase activity
A	0003917	molecular_function	DNA topoisomerase type I (single strand cut, ATP-independent) activity
A	0006265	biological_process	DNA topological change
A	0044423	cellular_component	virion component

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE VO4 A 600

Chain	Residue
A	ARG130
A	ARG223
A	HIS265
A	TYR274
A	HOH404
B	DT511
C	DA512

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Functional Information from PROSITE/UniProt

site_id	PS00176
Number of Residues	19
Details	TOPO_IB_1 Topoisomerase (Topo) IB-type active site signature. EvvghtpSISKraYMattI

Chain	Residue	Details
A	GLU261-ILE279

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: O-(3'-phospho-DNA)-tyrosine intermediate => ECO:0000255|PROSITE-ProRule:PRU01382, ECO:0000269|PubMed:16885024

Chain	Residue	Details
A	TYR274

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site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: Involved in religation => ECO:0000305|PubMed:16885024

Chain	Residue	Details
A	ASP168

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