3IGC
Smallpox virus topoisomerase-DNA transition state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003916 | molecular_function | DNA topoisomerase activity |
| A | 0003917 | molecular_function | DNA topoisomerase type I (single strand cut, ATP-independent) activity |
| A | 0006265 | biological_process | DNA topological change |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0044423 | cellular_component | virion component |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE VO4 A 600 |
| Chain | Residue |
| A | ARG130 |
| A | ARG223 |
| A | HIS265 |
| A | TYR274 |
| A | HOH404 |
| B | DT511 |
| C | DA512 |
Functional Information from PROSITE/UniProt
| site_id | PS00176 |
| Number of Residues | 19 |
| Details | TOPO_IB_1 Topoisomerase (Topo) IB-type active site signature. EvvghtpSISKraYMattI |
| Chain | Residue | Details |
| A | GLU261-ILE279 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"O-(3'-phospho-DNA)-tyrosine intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU01382","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16885024","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Site: {"description":"Involved in religation","evidences":[{"source":"PubMed","id":"16885024","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
