3IFC
Human muscle fructose-1,6-bisphosphatase E69Q mutant in complex with AMP and alpha fructose-6-phosphate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Fructose-1,6-bisphosphatase isozyme 2 | polymer | 338 | 36665.9 | 4 | UniProt (O00757) Pfam (PF00316) Pfam (PF18913) | Homo sapiens (human) | FBPase 2, D-fructose-1,6-bisphosphate 1-phosphohydrolase 2 |
| 2 | E, M, R, W (A, B, C, D) | ADENOSINE MONOPHOSPHATE | non-polymer | 347.2 | 4 | Chemie (AMP) | |||
| 3 | F, N, S, X (A, B, C, D) | 6-O-phosphono-alpha-D-fructofuranose | non-polymer | 260.1 | 4 | Chemie (P6P) | |||
| 4 | G, H, I, O, P... (A, B, C, D) | SULFATE ION | non-polymer | 96.1 | 9 | Chemie (SO4) | |||
| 5 | AA, J, K, L, Q... (D, A, B, C) | GLYCEROL | non-polymer | 92.1 | 6 | Chemie (GOL) | |||
| 6 | BA, CA, DA, EA (A, B, C, D) | water | water | 18.0 | 702 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 338 (UniProt: O00757)
| PDB | External Database | Details |
|---|---|---|
| Gln 69 | Glu 70 | engineered mutation |
| Leu 85 | Val 86 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 146663.6 | |
| Non-Polymers* | Number of molecules | 23 |
| Total formula weight | 3846.6 | |
| All* | Total formula weight | 150510.2 |
