3IEI
Crystal structure of human leucine carboxylmethyltransferase-1 in complex with S-adenosyl homocysteine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Leucine carboxyl methyltransferase 1 | polymer | 334 | 38504.2 | 8 | UniProt (Q9UIC8) Pfam (PF04072) | Homo sapiens (human) | Protein-leucine O-methyltransferase |
| 2 | I, K, N, P, S... (A, B, C, D, E...) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 8 | Chemie (SAH) PubChem (16760024) PubChem (25210495) PubChem (177678424) PubChem (21125603) PubChem (25203782) PubChem (52224400) PubChem (44361184) PubChem (46936206) PubChem (50989525) PubChem (51380914) PubChem (6419189) PubChem (52224398) PubChem (57544532) PubChem (164157219) PubChem (59046843) PubChem (59170628) PubChem (59576228) PubChem (66805708) PubChem (70689219) PubChem (70702054) PubChem (70832431) PubChem (118374891) PubChem (118560068) PubChem (193) PubChem (13792) PubChem (189149) PubChem (439155) PubChem (5284331) PubChem (126969526) PubChem (71170554) PubChem (129105892) PubChem (13231890) PubChem (143518505) PubChem (154578335) PubChem (163054214) PubChem (163335525) | |||
| 3 | BA, J, M, O, R... (H, A, B, C, D...) | GLYCEROL | non-polymer | 92.1 | 8 | Chemie (GOL) PubChem (753) | |||
| 4 | AA, L, Q, T (H, B, D, E) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 4 | Chemie (MES) PubChem (4478249) | |||
| 5 | CA, DA, EA, FA, GA... (A, B, C, D, E...) | water | water | 18.0 | 1851 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H: 1 - 334 (UniProt: Q9UIC8)
| PDB | External Database | Details |
|---|---|---|
| Met 19 | Cys 19 | engineered mutation |
| Glu 21 | Ala 21 | engineered mutation |
| Asn 22 | Asp 22 | engineered mutation |
| Ser 115 | Pro 115 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 308033.7 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 4593.0 | |
| All* | Total formula weight | 312626.7 |
