3IEI

Crystal structure of human leucine carboxylmethyltransferase-1 in complex with S-adenosyl homocysteine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000086	biological_process	G2/M transition of mitotic cell cycle
A	0003880	molecular_function	protein C-terminal carboxyl O-methyltransferase activity
A	0005515	molecular_function	protein binding
A	0005654	cellular_component	nucleoplasm
A	0005829	cellular_component	cytosol
A	0006479	biological_process	protein methylation
A	0006481	biological_process	C-terminal protein methylation
A	0008168	molecular_function	methyltransferase activity
A	0008276	molecular_function	protein methyltransferase activity
A	0008757	molecular_function	S-adenosylmethionine-dependent methyltransferase activity
A	0010906	biological_process	regulation of glucose metabolic process
A	0018423	molecular_function	protein C-terminal leucine carboxyl O-methyltransferase activity
A	0031333	biological_process	negative regulation of protein-containing complex assembly
A	0032259	biological_process	methylation
A	0036211	biological_process	protein modification process
A	0042981	biological_process	regulation of apoptotic process
A	0090266	biological_process	regulation of mitotic cell cycle spindle assembly checkpoint
B	0000086	biological_process	G2/M transition of mitotic cell cycle
B	0003880	molecular_function	protein C-terminal carboxyl O-methyltransferase activity
B	0005515	molecular_function	protein binding
B	0005654	cellular_component	nucleoplasm
B	0005829	cellular_component	cytosol
B	0006479	biological_process	protein methylation
B	0006481	biological_process	C-terminal protein methylation
B	0008168	molecular_function	methyltransferase activity
B	0008276	molecular_function	protein methyltransferase activity
B	0008757	molecular_function	S-adenosylmethionine-dependent methyltransferase activity
B	0010906	biological_process	regulation of glucose metabolic process
B	0018423	molecular_function	protein C-terminal leucine carboxyl O-methyltransferase activity
B	0031333	biological_process	negative regulation of protein-containing complex assembly
B	0032259	biological_process	methylation
B	0036211	biological_process	protein modification process
B	0042981	biological_process	regulation of apoptotic process
B	0090266	biological_process	regulation of mitotic cell cycle spindle assembly checkpoint
C	0000086	biological_process	G2/M transition of mitotic cell cycle
C	0003880	molecular_function	protein C-terminal carboxyl O-methyltransferase activity
C	0005515	molecular_function	protein binding
C	0005654	cellular_component	nucleoplasm
C	0005829	cellular_component	cytosol
C	0006479	biological_process	protein methylation
C	0006481	biological_process	C-terminal protein methylation
C	0008168	molecular_function	methyltransferase activity
C	0008276	molecular_function	protein methyltransferase activity
C	0008757	molecular_function	S-adenosylmethionine-dependent methyltransferase activity
C	0010906	biological_process	regulation of glucose metabolic process
C	0018423	molecular_function	protein C-terminal leucine carboxyl O-methyltransferase activity
C	0031333	biological_process	negative regulation of protein-containing complex assembly
C	0032259	biological_process	methylation
C	0036211	biological_process	protein modification process
C	0042981	biological_process	regulation of apoptotic process
C	0090266	biological_process	regulation of mitotic cell cycle spindle assembly checkpoint
D	0000086	biological_process	G2/M transition of mitotic cell cycle
D	0003880	molecular_function	protein C-terminal carboxyl O-methyltransferase activity
D	0005515	molecular_function	protein binding
D	0005654	cellular_component	nucleoplasm
D	0005829	cellular_component	cytosol
D	0006479	biological_process	protein methylation
D	0006481	biological_process	C-terminal protein methylation
D	0008168	molecular_function	methyltransferase activity
D	0008276	molecular_function	protein methyltransferase activity
D	0008757	molecular_function	S-adenosylmethionine-dependent methyltransferase activity
D	0010906	biological_process	regulation of glucose metabolic process
D	0018423	molecular_function	protein C-terminal leucine carboxyl O-methyltransferase activity
D	0031333	biological_process	negative regulation of protein-containing complex assembly
D	0032259	biological_process	methylation
D	0036211	biological_process	protein modification process
D	0042981	biological_process	regulation of apoptotic process
D	0090266	biological_process	regulation of mitotic cell cycle spindle assembly checkpoint
E	0000086	biological_process	G2/M transition of mitotic cell cycle
E	0003880	molecular_function	protein C-terminal carboxyl O-methyltransferase activity
E	0005515	molecular_function	protein binding
E	0005654	cellular_component	nucleoplasm
E	0005829	cellular_component	cytosol
E	0006479	biological_process	protein methylation
E	0006481	biological_process	C-terminal protein methylation
E	0008168	molecular_function	methyltransferase activity
E	0008276	molecular_function	protein methyltransferase activity
E	0008757	molecular_function	S-adenosylmethionine-dependent methyltransferase activity
E	0010906	biological_process	regulation of glucose metabolic process
E	0018423	molecular_function	protein C-terminal leucine carboxyl O-methyltransferase activity
E	0031333	biological_process	negative regulation of protein-containing complex assembly
E	0032259	biological_process	methylation
E	0036211	biological_process	protein modification process
E	0042981	biological_process	regulation of apoptotic process
E	0090266	biological_process	regulation of mitotic cell cycle spindle assembly checkpoint
F	0000086	biological_process	G2/M transition of mitotic cell cycle
F	0003880	molecular_function	protein C-terminal carboxyl O-methyltransferase activity
F	0005515	molecular_function	protein binding
F	0005654	cellular_component	nucleoplasm
F	0005829	cellular_component	cytosol
F	0006479	biological_process	protein methylation
F	0006481	biological_process	C-terminal protein methylation
F	0008168	molecular_function	methyltransferase activity
F	0008276	molecular_function	protein methyltransferase activity
F	0008757	molecular_function	S-adenosylmethionine-dependent methyltransferase activity
F	0010906	biological_process	regulation of glucose metabolic process
F	0018423	molecular_function	protein C-terminal leucine carboxyl O-methyltransferase activity
F	0031333	biological_process	negative regulation of protein-containing complex assembly
F	0032259	biological_process	methylation
F	0036211	biological_process	protein modification process
F	0042981	biological_process	regulation of apoptotic process
F	0090266	biological_process	regulation of mitotic cell cycle spindle assembly checkpoint
G	0000086	biological_process	G2/M transition of mitotic cell cycle
G	0003880	molecular_function	protein C-terminal carboxyl O-methyltransferase activity
G	0005515	molecular_function	protein binding
G	0005654	cellular_component	nucleoplasm
G	0005829	cellular_component	cytosol
G	0006479	biological_process	protein methylation
G	0006481	biological_process	C-terminal protein methylation
G	0008168	molecular_function	methyltransferase activity
G	0008276	molecular_function	protein methyltransferase activity
G	0008757	molecular_function	S-adenosylmethionine-dependent methyltransferase activity
G	0010906	biological_process	regulation of glucose metabolic process
G	0018423	molecular_function	protein C-terminal leucine carboxyl O-methyltransferase activity
G	0031333	biological_process	negative regulation of protein-containing complex assembly
G	0032259	biological_process	methylation
G	0036211	biological_process	protein modification process
G	0042981	biological_process	regulation of apoptotic process
G	0090266	biological_process	regulation of mitotic cell cycle spindle assembly checkpoint
H	0000086	biological_process	G2/M transition of mitotic cell cycle
H	0003880	molecular_function	protein C-terminal carboxyl O-methyltransferase activity
H	0005515	molecular_function	protein binding
H	0005654	cellular_component	nucleoplasm
H	0005829	cellular_component	cytosol
H	0006479	biological_process	protein methylation
H	0006481	biological_process	C-terminal protein methylation
H	0008168	molecular_function	methyltransferase activity
H	0008276	molecular_function	protein methyltransferase activity
H	0008757	molecular_function	S-adenosylmethionine-dependent methyltransferase activity
H	0010906	biological_process	regulation of glucose metabolic process
H	0018423	molecular_function	protein C-terminal leucine carboxyl O-methyltransferase activity
H	0031333	biological_process	negative regulation of protein-containing complex assembly
H	0032259	biological_process	methylation
H	0036211	biological_process	protein modification process
H	0042981	biological_process	regulation of apoptotic process
H	0090266	biological_process	regulation of mitotic cell cycle spindle assembly checkpoint

Functional Information from PDB Data

site_id	AC1
Number of Residues	21
Details	BINDING SITE FOR RESIDUE SAH A 601

Chain	Residue
A	VAL26
A	PHE123
A	ALA170
A	ASP171
A	LEU172
A	ARG173
A	GLU198
A	CYS199
A	VAL200
A	HOH335
A	HOH344
A	THR29
A	HOH354
A	HOH1482
A	CYS30
A	LYS37
A	ARG73
A	GLY98
A	ALA99
A	GLY100
A	ASP122

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 1912

Chain	Residue
A	ILE66
A	ARG73
A	TYR228
A	LEU311
A	TYR315
A	HOH820
A	HOH822

---

site_id	AC3
Number of Residues	19
Details	BINDING SITE FOR RESIDUE SAH B 601

Chain	Residue
B	VAL26
B	THR29
B	CYS30
B	LYS37
B	ARG73
B	GLY98
B	ALA99
B	GLY100
B	ASP122
B	PHE123
B	ALA170
B	ASP171
B	LEU172
B	ARG173
B	GLU198
B	CYS199
B	VAL200
B	HOH351
B	HOH359

---

site_id	AC4
Number of Residues	13
Details	BINDING SITE FOR RESIDUE MES B 1903

Chain	Residue
A	LYS265
A	SER277
A	ALA278
A	TRP319
A	THR333
A	HOH1229
B	LYS265
B	SER277
B	ALA278
B	GLU283
B	HOH455
B	HOH807
B	HOH1662

---

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL B 1913

Chain	Residue
B	ILE66
B	TYR70
B	ARG73
B	TYR228
B	TYR315
B	HOH826
B	HOH827
B	HOH885

---

site_id	AC6
Number of Residues	21
Details	BINDING SITE FOR RESIDUE SAH C 601

Chain	Residue
C	VAL26
C	THR29
C	CYS30
C	LYS37
C	ARG73
C	GLY98
C	ALA99
C	GLY100
C	ASP122
C	PHE123
C	ILE126
C	ALA170
C	ASP171
C	LEU172
C	ARG173
C	GLU198
C	CYS199
C	VAL200
C	HOH336
C	HOH347
C	HOH350

---

site_id	AC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL C 1914

Chain	Residue
C	GLY69
C	TYR70
C	ARG73
C	TYR228
C	TYR315
C	HOH812
C	HOH813
C	HOH1820

---

site_id	AC8
Number of Residues	22
Details	BINDING SITE FOR RESIDUE SAH D 601

Chain	Residue
D	CYS30
D	LYS37
D	ARG73
D	GLY98
D	ALA99
D	GLY100
D	ASP122
D	PHE123
D	ALA170
D	ASP171
D	LEU172
D	ARG173
D	GLU198
D	CYS199
D	VAL200
D	HOH342
D	HOH353
D	HOH378
D	HOH513
D	HOH1697
D	VAL26
D	THR29

---

site_id	AC9
Number of Residues	10
Details	BINDING SITE FOR RESIDUE MES D 1902

Chain	Residue
C	LYS265
C	SER277
C	ALA278
C	TRP319
C	THR333
D	LYS265
D	SER277
D	ALA278
D	GLU283
D	HOH565

---

site_id	BC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL D 1915

Chain	Residue
D	ILE66
D	GLY69
D	TYR70
D	ARG73
D	TYR228
D	TYR315
D	HOH390
D	HOH622
D	HOH828
D	HOH1580

---

site_id	BC2
Number of Residues	22
Details	BINDING SITE FOR RESIDUE SAH E 601

Chain	Residue
E	VAL26
E	THR29
E	CYS30
E	LYS37
E	ARG73
E	GLY98
E	ALA99
E	GLY100
E	ASP122
E	PHE123
E	ALA170
E	ASP171
E	LEU172
E	ARG173
E	GLU198
E	CYS199
E	VAL200
E	HOH340
E	HOH347
E	HOH358
E	HOH382
E	HOH685

---

site_id	BC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE MES E 1901

Chain	Residue
E	LYS265
E	SER277
E	ALA278
E	GLU283
E	HOH366
F	LYS265
F	ALA276
F	SER277
F	ALA278
F	TRP319
F	THR333

---

site_id	BC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL E 1916

Chain	Residue
E	ILE66
E	GLY69
E	TYR70
E	ARG73
E	TYR228
E	TYR315
E	HOH402
E	HOH624
E	HOH818

---

site_id	BC5
Number of Residues	21
Details	BINDING SITE FOR RESIDUE SAH F 601

Chain	Residue
F	VAL26
F	THR29
F	CYS30
F	LYS37
F	ARG73
F	GLY98
F	ALA99
F	GLY100
F	ASP122
F	PHE123
F	ALA170
F	ASP171
F	LEU172
F	ARG173
F	GLU198
F	CYS199
F	VAL200
F	HOH335
F	HOH357
F	HOH373
F	HOH1064

---

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL F 1917

Chain	Residue
F	TYR70
F	ARG73
F	TYR228
F	TYR315
F	HOH816

---

site_id	BC7
Number of Residues	20
Details	BINDING SITE FOR RESIDUE SAH G 601

Chain	Residue
G	VAL26
G	THR29
G	CYS30
G	LYS37
G	ARG73
G	GLY98
G	ALA99
G	GLY100
G	ASP122
G	PHE123
G	ALA170
G	ASP171
G	LEU172
G	ARG173
G	GLU198
G	CYS199
G	VAL200
G	HOH335
G	HOH339
G	HOH352

---

site_id	BC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL G 1911

Chain	Residue
G	ILE66
G	TYR70
G	ARG73
G	TYR228
G	LEU311
G	TYR315
G	HOH376
G	HOH823

---

site_id	BC9
Number of Residues	21
Details	BINDING SITE FOR RESIDUE SAH H 601

Chain	Residue
H	VAL26
H	THR29
H	CYS30
H	LYS37
H	ARG73
H	GLY98
H	ALA99
H	GLY100
H	ASP122
H	PHE123
H	ALA170
H	ASP171
H	LEU172
H	ARG173
H	GLU198
H	CYS199
H	VAL200
H	HOH339
H	HOH356
H	HOH434
H	HOH1142

---

site_id	CC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE MES H 1904

Chain	Residue
G	LEU261
G	LYS265
G	SER277
G	ALA278
G	GLU283
G	HOH365
H	LYS265
H	SER277
H	ALA278
H	TRP319
H	THR333
H	HOH838

---

site_id	CC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL H 1918

Chain	Residue
H	GLY69
H	TYR70
H	ARG73
H	TYR228
H	TYR315
H	HOH824
H	HOH825

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	48
Details	BINDING: BINDING => ECO:0000269|PubMed:21206058, ECO:0007744|PDB:3O7W

Chain	Residue	Details
A	LYS37
B	ASP122
B	ASP171
B	GLU198
C	LYS37
C	ARG73
C	GLY98
C	ASP122
C	ASP171
C	GLU198
D	LYS37
A	ARG73
D	ARG73
D	GLY98
D	ASP122
D	ASP171
D	GLU198
E	LYS37
E	ARG73
E	GLY98
E	ASP122
E	ASP171
A	GLY98
E	GLU198
F	LYS37
F	ARG73
F	GLY98
F	ASP122
F	ASP171
F	GLU198
G	LYS37
G	ARG73
G	GLY98
A	ASP122
G	ASP122
G	ASP171
G	GLU198
H	LYS37
H	ARG73
H	GLY98
H	ASP122
H	ASP171
H	GLU198
A	ASP171
A	GLU198
B	LYS37
B	ARG73
B	GLY98

---