3I8V

Crystal structure of human PDE4a with 4-(3-butoxy-4-methoxyphenyl)methyl-2-imidazolidone

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	polymer	354	40689.2	2	UniProt (P27815) Pfam (PF00233) In PDB	Homo sapiens (human)	DPDE2, PDE46
2	A, B	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
3	A, B	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
4	A, B	(4R)-4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one	non-polymer		278.3	2	Chemie (0MO)
5	A, B	GLYCEROL	non-polymer		92.1	3	Chemie (GOL)
6	A	COBALT (II) ION	non-polymer		58.9	1	Chemie (CO)
7		water	water		18.0	349	Chemie (HOH)

Sequence modifications

A, B: 290 - 622 (UniProt: P27815)

PDB	External Database	Details
Met 269	-	expression tag
Gly 270	-	expression tag
Ser 271	-	expression tag
Ser 272	-	expression tag
His 273	-	expression tag
His 274	-	expression tag
His 275	-	expression tag
His 276	-	expression tag
His 277	-	expression tag
His 278	-	expression tag
Ser 279	-	expression tag
Ser 280	-	expression tag
Gly 281	-	expression tag
Leu 282	-	expression tag
Val 283	-	expression tag
Pro 284	-	expression tag
Arg 285	-	expression tag
Gly 286	-	expression tag
Ser 287	-	expression tag
His 288	-	expression tag
Met 289	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	81378.5
Non-Polymers*	Number of molecules	10
	Total formula weight	1071.3
All*	Total formula weight	82449.8

*Water molecules are not included.