3I8V
Crystal structure of human PDE4a with 4-(3-butoxy-4-methoxyphenyl)methyl-2-imidazolidone
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | polymer | 354 | 40689.2 | 2 | UniProt (P27815) Pfam (PF00233) | Homo sapiens (human) | DPDE2, PDE46 |
| 2 | C, H (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | D, I (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | E, J (A, B) | (4R)-4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one | non-polymer | 278.3 | 2 | Chemie (0MO) | |||
| 5 | F, K, L (A, B) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 6 | G (A) | COBALT (II) ION | non-polymer | 58.9 | 1 | Chemie (CO) | |||
| 7 | M, N (A, B) | water | water | 18.0 | 349 | Chemie (HOH) |
Sequence modifications
A, B: 290 - 622 (UniProt: P27815)
| PDB | External Database | Details |
|---|---|---|
| Met 269 | - | expression tag |
| Gly 270 | - | expression tag |
| Ser 271 | - | expression tag |
| Ser 272 | - | expression tag |
| His 273 | - | expression tag |
| His 274 | - | expression tag |
| His 275 | - | expression tag |
| His 276 | - | expression tag |
| His 277 | - | expression tag |
| His 278 | - | expression tag |
| Ser 279 | - | expression tag |
| Ser 280 | - | expression tag |
| Gly 281 | - | expression tag |
| Leu 282 | - | expression tag |
| Val 283 | - | expression tag |
| Pro 284 | - | expression tag |
| Arg 285 | - | expression tag |
| Gly 286 | - | expression tag |
| Ser 287 | - | expression tag |
| His 288 | - | expression tag |
| Met 289 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 81378.5 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1071.3 | |
| All* | Total formula weight | 82449.8 |
