3I55
Co-crystal structure of Mycalamide A Bound to the Large Ribosomal Subunit
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (0) | 23S ribosomal RNA | polymer | 2923 | 946463.5 | 1 | GenBank (AY596297.1) | Haloarcula marismortui ATCC 43049 | |
| 2 | B (A) | 50S ribosomal protein L2P | polymer | 240 | 25354.7 | 1 | UniProt (P20276) Pfam (PF00181) Pfam (PF03947) | Haloarcula marismortui (Halobacterium marismortui) | Hmal2, Hl4 |
| 3 | C (B) | 50S ribosomal protein L3P | polymer | 338 | 37396.4 | 1 | UniProt (P20279) Pfam (PF00297) | Haloarcula marismortui (Halobacterium marismortui) | Hmal3, Hl1 |
| 4 | D (C) | 50S ribosomal protein L4P | polymer | 246 | 26457.1 | 1 | UniProt (P12735) Pfam (PF00573) | Haloarcula marismortui (Halobacterium marismortui) | Hmal4, Hl6 |
| 5 | E (D) | 50S ribosomal protein L5P | polymer | 177 | 19551.7 | 1 | UniProt (P14124) Pfam (PF00281) Pfam (PF00673) | Haloarcula marismortui (Halobacterium marismortui) | Hmal5, Hl13 |
| 6 | F (E) | 50S ribosomal protein L6P | polymer | 178 | 19961.7 | 1 | UniProt (P14135) Pfam (PF00347) | Haloarcula marismortui (Halobacterium marismortui) | Hmal6, Hl10 |
| 7 | G (F) | 50S ribosomal protein L7Ae | polymer | 120 | 12791.9 | 1 | UniProt (P12743) Pfam (PF01248) | Haloarcula marismortui (Halobacterium marismortui) | Hs6 |
| 8 | H (G) | 50S ribosomal protein L10E | polymer | 348 | 37169.8 | 1 | UniProt (P15825) Pfam (PF00466) Pfam (PF17777) | Haloarcula marismortui (Halobacterium marismortui) | Ribosomal protein L10, Acidic ribosomal protein P0 homolog, L10E, HMal10 |
| 9 | I (H) | 50S ribosomal protein L10e | polymer | 174 | 19645.3 | 1 | UniProt (P60617) Pfam (PF00252) | Haloarcula marismortui (Halobacterium marismortui) | |
| 10 | J (I) | 50S ribosomal protein L11P | polymer | 162 | 17097.5 | 1 | UniProt (P14122) Pfam (PF03946) Pfam (PF00298) | Haloarcula marismortui (Halobacterium marismortui) | Hmal11 |
| 11 | K (J) | 50S ribosomal protein L13P | polymer | 145 | 16249.2 | 1 | UniProt (P29198) Pfam (PF00572) | Haloarcula marismortui (Halobacterium marismortui) | Hmal13 |
| 12 | L (K) | 50S ribosomal protein L14P | polymer | 132 | 14216.2 | 1 | UniProt (P22450) Pfam (PF00238) | Haloarcula marismortui (Halobacterium marismortui) | Hmal14, Hl27 |
| 13 | M (L) | 50S ribosomal protein L15P | polymer | 165 | 18005.4 | 1 | UniProt (P12737) Pfam (PF00828) | Haloarcula marismortui (Halobacterium marismortui) | Hmal15, Hl9 |
| 14 | N (M) | 50S ribosomal protein L15e | polymer | 194 | 22143.9 | 1 | UniProt (P60618) Pfam (PF00827) | Haloarcula marismortui (Halobacterium marismortui) | 50S ribosomal protein LC12 |
| 15 | O (N) | 50S ribosomal protein L18P | polymer | 187 | 20640.9 | 1 | UniProt (P14123) Pfam (PF17144) | Haloarcula marismortui (Halobacterium marismortui) | Hmal18, Hl12 |
| 16 | P (O) | 50S ribosomal protein L18e | polymer | 116 | 12438.9 | 1 | UniProt (P12733) Pfam (PF00828) | Haloarcula marismortui (Halobacterium marismortui) | Hl29, L19 |
| 17 | Q (P) | 50S ribosomal protein L19e | polymer | 149 | 16796.5 | 1 | UniProt (P14119) Pfam (PF01280) | Haloarcula marismortui (Halobacterium marismortui) | Hmal19, Hl24 |
| 18 | R (Q) | 50S ribosomal protein L21e | polymer | 96 | 10567.8 | 1 | UniProt (P12734) Pfam (PF01157) | Haloarcula marismortui (Halobacterium marismortui) | Hl31 |
| 19 | S (R) | 50S ribosomal protein L22P | polymer | 155 | 16966.9 | 1 | UniProt (P10970) Pfam (PF00237) | Haloarcula marismortui (Halobacterium marismortui) | Hmal22, Hl23 |
| 20 | T (S) | 50S ribosomal protein L23P | polymer | 85 | 9612.5 | 1 | UniProt (P12732) Pfam (PF00276) | Haloarcula marismortui (Halobacterium marismortui) | Hmal23, Hl25, L21 |
| 21 | U (T) | 50S ribosomal protein L24P | polymer | 120 | 13671.0 | 1 | UniProt (P10972) Pfam (PF16906) Pfam (PF00467) | Haloarcula marismortui (Halobacterium marismortui) | Hmal24, Hl16, Hl15 |
| 22 | V (U) | 50S ribosomal protein L24e | polymer | 66 | 7233.7 | 1 | UniProt (P14116) Pfam (PF01246) | Haloarcula marismortui (Halobacterium marismortui) | Hl21/Hl22 |
| 23 | W (V) | 50S ribosomal protein L29P | polymer | 71 | 7889.9 | 1 | UniProt (P10971) Pfam (PF00831) | Haloarcula marismortui (Halobacterium marismortui) | Hmal29, Hl33 |
| 24 | X (W) | 50S ribosomal protein L30P | polymer | 154 | 17062.9 | 1 | UniProt (P14121) Pfam (PF00327) | Haloarcula marismortui (Halobacterium marismortui) | Hmal30, Hl20, Hl16 |
| 25 | Y (X) | 50S ribosomal protein L31e | polymer | 92 | 10384.6 | 1 | UniProt (P18138) Pfam (PF01198) | Haloarcula marismortui (Halobacterium marismortui) | L34, Hl30 |
| 26 | Z (Y) | 50S ribosomal protein L32e | polymer | 241 | 26455.7 | 1 | UniProt (P12736) Pfam (PF14520) Pfam (PF01655) | Haloarcula marismortui (Halobacterium marismortui) | Hl5 |
| 27 | AA (Z) | 50S ribosomal protein L37Ae | polymer | 116 | 12900.3 | 1 | UniProt (P60619) Pfam (PF01780) | Haloarcula marismortui (Halobacterium marismortui) | |
| 28 | BA (1) | 50S ribosomal protein L37e | polymer | 57 | 6330.2 | 1 | UniProt (P32410) Pfam (PF01907) | Haloarcula marismortui (Halobacterium marismortui) | L35e |
| 29 | CA (2) | 50S ribosomal protein L39e | polymer | 50 | 6133.1 | 1 | UniProt (P22452) Pfam (PF00832) | Haloarcula marismortui (Halobacterium marismortui) | Hl39e, Hl46e |
| 30 | DA (3) | 50S ribosomal protein L44E | polymer | 92 | 10815.2 | 1 | UniProt (P32411) Pfam (PF00935) | Haloarcula marismortui (Halobacterium marismortui) | La, Hla |
| 31 | EA (9) | 5S ribosomal RNA | polymer | 122 | 39303.4 | 1 | GenBank (AF034620.1) | Haloarcula marismortui | |
| 32 | FA (4) | DNA/RNA (5'-R(*CP*CP*(5AA)P*(2OP)P*(PO2)P*AP*CP*C)-3') | polymer | 8 | 1962.3 | 1 | |||
| 33 | AB, AC, AD, BB, BC... (0, B, T, Y, 2...) | MAGNESIUM ION | non-polymer | 24.3 | 93 | Chemie (MG) | |||
| 34 | LD, MD (0) | POTASSIUM ION | non-polymer | 39.1 | 2 | Chemie (K) | |||
| 35 | AE, AF, AL, BE, BF... (0, R, B, S, C...) | SODIUM ION | non-polymer | 23.0 | 75 | Chemie (NA) | |||
| 36 | AG, AK, BG, CG, CL... (0, A, R, B, Y...) | CHLORIDE ION | non-polymer | 35.5 | 22 | Chemie (CL) | |||
| 37 | AH, AI, AJ, BH, BI... (0, A, R, S, B...) | STRONTIUM ION | non-polymer | 87.6 | 108 | Chemie (SR) | |||
| 38 | XJ (0) | Mycalamide A | non-polymer | 503.6 | 1 | Chemie (MYL) | |||
| 39 | HL, KL, LL, PL, WK (U, Z, 1, 3, O) | CADMIUM ION | non-polymer | 112.4 | 5 | Chemie (CD) | |||
| 40 | AM, AN, BM, BN, CM... (0, Z, A, 1, B...) | water | water | 18.0 | 7823 | Chemie (HOH) |
Sequence modifications
Z: 25 - 116 (UniProt: P60619)
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | expression tag |
| Ser 2 | - | expression tag |
| Pro 3 | - | expression tag |
| Arg 4 | - | expression tag |
| Ala 5 | - | expression tag |
| Arg 6 | - | expression tag |
| Arg 7 | - | expression tag |
| Glu 8 | - | expression tag |
| Pro 9 | - | expression tag |
| Asn 10 | - | expression tag |
| Leu 11 | - | expression tag |
| Glu 12 | - | expression tag |
| Gly 13 | - | expression tag |
| Leu 14 | - | expression tag |
| Met 15 | - | expression tag |
| Trp 16 | - | expression tag |
| Pro 17 | - | expression tag |
| Leu 18 | - | expression tag |
| Gly 19 | - | expression tag |
| Gly 20 | - | expression tag |
| Gln 21 | - | expression tag |
| Gln 22 | - | expression tag |
| Thr 23 | - | expression tag |
| Thr 24 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 32 |
| Total formula weight | 1479670.4 | |
| Non-Polymers* | Number of molecules | 306 |
| Total formula weight | 15371.4 | |
| All* | Total formula weight | 1495041.8 |
