3I08
Crystal structure of the S1-cleaved Notch1 Negative Regulatory Region (NRR)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C | Neurogenic locus notch homolog protein 1 | polymer | 220 | 24595.3 | 2 | UniProt (P46531) Pfam (PF00066) Pfam (PF06816) In PDB | Homo sapiens (human) | Notch 1, hN1, Translocation-associated notch protein TAN-1, Notch 1 extracellular truncation, Notch 1 intracellular domain |
| 2 | B, D | Neurogenic locus notch homolog protein 1 | polymer | 69 | 7383.2 | 2 | UniProt (P46531) Pfam (PF07684) In PDB | Homo sapiens (human) | |
| 3 | A, C | CALCIUM ION | non-polymer | 40.1 | 6 | Chemie (CA) | |||
| 4 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 5 | water | water | 18.0 | 21 | Chemie (HOH) |
Sequence modifications
A, C: 1447 - 1665 (UniProt: P46531)
| PDB | External Database | Details |
|---|---|---|
| Gly 1446 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 63957.1 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 275.9 | |
| All* | Total formula weight | 64233.1 |
