Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

3I08

Crystal structure of the S1-cleaved Notch1 Negative Regulatory Region (NRR)

Functional Information from GO Data
ChainGOidnamespacecontents
A0016020cellular_componentmembrane
A0030154biological_processcell differentiation
B0007219biological_processNotch signaling pathway
B0007275biological_processmulticellular organism development
B0016020cellular_componentmembrane
B0030154biological_processcell differentiation
C0016020cellular_componentmembrane
C0030154biological_processcell differentiation
D0007219biological_processNotch signaling pathway
D0007275biological_processmulticellular organism development
D0016020cellular_componentmembrane
D0030154biological_processcell differentiation
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 1
ChainResidue
AASP1458
AASN1461
AVAL1463
ASER1465
AASP1476
AASP1479

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 1666
ChainResidue
AASP1507
AASP1518
AASP1521
ATYR1500
AASP1503
AHIS1505

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 1667
ChainResidue
AHIS1540
AASP1543
AHIS1545
AASP1547
AASP1558
AASP1561

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CL A 1668
ChainResidue
AHIS1471
ATRP1475
AASP1486
APRO1487
ATRP1488

site_idAC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA C 1
ChainResidue
CASP1458
CASN1461
CVAL1463
CSER1465
CASP1476
CASP1479

site_idAC6
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA C 1666
ChainResidue
CTYR1500
CASP1503
CHIS1505
CASP1507
CASP1518
CASP1521

site_idAC7
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA C 1667
ChainResidue
CHIS1540
CASP1543
CHIS1545
CASP1547
CASP1558
CASP1561

Functional Information from PROSITE/UniProt
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. VCSLqcNnHACGWDG
ChainResidueDetails
AVAL1463-GLY1477

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues80
DetailsRepeat: {"description":"LNR 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00525","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues82
DetailsRepeat: {"description":"LNR 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00525","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues78
DetailsRepeat: {"description":"LNR 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00525","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues8
DetailsBinding site: {}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues2
DetailsSite: {"description":"Cleavage; by ADAM17","evidences":[{"source":"UniProtKB","id":"Q01705","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues2
DetailsGlycosylation: {"description":"O-linked (GalNAc...) threonine","evidences":[{"source":"PubMed","id":"24226769","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

243083

PDB entries from 2025-10-15

PDB statisticsPDBj update infoContact PDBjnumon