3HXI
Crystal structure of Schistosome eIF4E complexed with m7GpppG and 4E-BP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Eukaryotic Translation Initiation 4E | polymer | 189 | 22237.8 | 1 | Schistosoma mansoni | ||
| 2 | B (C) | Eukaryotic translation initiation factor 4E-binding protein 1 | polymer | 21 | 2432.8 | 1 | UniProt (Q13541) | Homo sapiens | eIF4E-binding protein 1, 4E-BP1, Phosphorylated heat- and acid-stable protein regulated by insulin 1, PHAS-I |
| 3 | C (A) | 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE | non-polymer | 803.4 | 1 | Chemie (GTG) | |||
| 4 | D, E (A, C) | water | water | 18.0 | 112 | Chemie (HOH) |
Sequence modifications
C: 5 - 21 (UniProt: Q13541)
| PDB | External Database | Details |
|---|---|---|
| Ser 1 | - | insertion |
| Gly 2 | - | insertion |
| Ser 3 | - | insertion |
| Gly 4 | - | insertion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 24670.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 803.4 | |
| All* | Total formula weight | 25474.1 |
