3HVQ

Crystal structure of a complex between Protein Phosphatase 1 alpha (PP1) and the PP1 binding and PDZ domains of Neurabin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Serine/threonine-protein phosphatase PP1-alpha catalytic subunit	polymer	329	37349.8	2	UniProt (P62136) Pfam (PF16891) Pfam (PF00149)	Homo sapiens (human)	PP-1A
2	C, D (C, D)	Neurabin-1	polymer	170	18849.9	2	UniProt (O35867) Pfam (PF17817) Pfam (PF00595)	Rattus norvegicus (rat)	Neurabin-I, Neural tissue-specific F-actin-binding protein I, Protein phosphatase 1 regulatory subunit 9A, p180, PP1bp175
3	E, F, H, I (A, B)	MANGANESE (II) ION	non-polymer		54.9	4	Chemie (MN)
4	G, J (A, B)	PHOSPHATE ION	non-polymer		95.0	2	Chemie (PO4)
5	K, L, M (B)	GLYCEROL	non-polymer		92.1	3	Chemie (GOL)
6	N, O, P, Q (A, B, C, D)	water	water		18.0	560	Chemie (HOH)

Sequence modifications

A, B: 7 - 330 (UniProt: P62136)

PDB	External Database	Details
Gly 2	-	expression tag
His 3	-	expression tag
Met 4	-	expression tag
Gly 5	-	expression tag
Ser 6	-	expression tag

C, D: 426 - 592 (UniProt: O35867)

PDB	External Database	Details
Gly 423	-	expression tag
His 424	-	expression tag
Met 425	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	112399.4
Non-Polymers*	Number of molecules	9
	Total formula weight	686.0
All*	Total formula weight	113085.4

*Water molecules are not included.