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3HVQ

Crystal structure of a complex between Protein Phosphatase 1 alpha (PP1) and the PP1 binding and PDZ domains of Neurabin

Functional Information from GO Data
ChainGOidnamespacecontents
A0000164cellular_componentprotein phosphatase type 1 complex
A0000781cellular_componentchromosome, telomeric region
A0001111biological_processRNA polymerase II promoter clearance
A0004721molecular_functionphosphoprotein phosphatase activity
A0004722molecular_functionprotein serine/threonine phosphatase activity
A0005506molecular_functioniron ion binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0005783cellular_componentendoplasmic reticulum
A0005814cellular_componentcentriole
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005912cellular_componentadherens junction
A0005977biological_processglycogen metabolic process
A0005979biological_processregulation of glycogen biosynthetic process
A0005981biological_processregulation of glycogen catabolic process
A0006470biological_processprotein dephosphorylation
A0008157molecular_functionprotein phosphatase 1 binding
A0010288biological_processresponse to lead ion
A0016787molecular_functionhydrolase activity
A0016791molecular_functionphosphatase activity
A0030324biological_processlung development
A0032922biological_processcircadian regulation of gene expression
A0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
A0034244biological_processnegative regulation of transcription elongation by RNA polymerase II
A0042587cellular_componentglycogen granule
A0042752biological_processregulation of circadian rhythm
A0043021molecular_functionribonucleoprotein complex binding
A0043025cellular_componentneuronal cell body
A0043153biological_processentrainment of circadian clock by photoperiod
A0043197cellular_componentdendritic spine
A0043204cellular_componentperikaryon
A0043247biological_processtelomere maintenance in response to DNA damage
A0043558biological_processregulation of translational initiation in response to stress
A0044877molecular_functionprotein-containing complex binding
A0045725biological_processpositive regulation of glycogen biosynthetic process
A0046872molecular_functionmetal ion binding
A0046914molecular_functiontransition metal ion binding
A0048754biological_processbranching morphogenesis of an epithelial tube
A0050821biological_processprotein stabilization
A0051301biological_processcell division
A0060828biological_processregulation of canonical Wnt signaling pathway
A0070062cellular_componentextracellular exosome
A0072357cellular_componentPTW/PP1 phosphatase complex
A0097225cellular_componentsperm midpiece
A0097229cellular_componentsperm end piece
A0098609biological_processcell-cell adhesion
A0098641molecular_functioncadherin binding involved in cell-cell adhesion
A0098793cellular_componentpresynapse
A0098794cellular_componentpostsynapse
A0098978cellular_componentglutamatergic synapse
A0180007molecular_functionRNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
A2000806biological_processpositive regulation of termination of RNA polymerase II transcription, poly(A)-coupled
A2001241biological_processpositive regulation of extrinsic apoptotic signaling pathway in absence of ligand
B0000164cellular_componentprotein phosphatase type 1 complex
B0000781cellular_componentchromosome, telomeric region
B0001111biological_processRNA polymerase II promoter clearance
B0004721molecular_functionphosphoprotein phosphatase activity
B0004722molecular_functionprotein serine/threonine phosphatase activity
B0005506molecular_functioniron ion binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005730cellular_componentnucleolus
B0005737cellular_componentcytoplasm
B0005783cellular_componentendoplasmic reticulum
B0005814cellular_componentcentriole
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005912cellular_componentadherens junction
B0005977biological_processglycogen metabolic process
B0005979biological_processregulation of glycogen biosynthetic process
B0005981biological_processregulation of glycogen catabolic process
B0006470biological_processprotein dephosphorylation
B0008157molecular_functionprotein phosphatase 1 binding
B0010288biological_processresponse to lead ion
B0016787molecular_functionhydrolase activity
B0016791molecular_functionphosphatase activity
B0030324biological_processlung development
B0032922biological_processcircadian regulation of gene expression
B0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
B0034244biological_processnegative regulation of transcription elongation by RNA polymerase II
B0042587cellular_componentglycogen granule
B0042752biological_processregulation of circadian rhythm
B0043021molecular_functionribonucleoprotein complex binding
B0043025cellular_componentneuronal cell body
B0043153biological_processentrainment of circadian clock by photoperiod
B0043197cellular_componentdendritic spine
B0043204cellular_componentperikaryon
B0043247biological_processtelomere maintenance in response to DNA damage
B0043558biological_processregulation of translational initiation in response to stress
B0044877molecular_functionprotein-containing complex binding
B0045725biological_processpositive regulation of glycogen biosynthetic process
B0046872molecular_functionmetal ion binding
B0046914molecular_functiontransition metal ion binding
B0048754biological_processbranching morphogenesis of an epithelial tube
B0050821biological_processprotein stabilization
B0051301biological_processcell division
B0060828biological_processregulation of canonical Wnt signaling pathway
B0070062cellular_componentextracellular exosome
B0072357cellular_componentPTW/PP1 phosphatase complex
B0097225cellular_componentsperm midpiece
B0097229cellular_componentsperm end piece
B0098609biological_processcell-cell adhesion
B0098641molecular_functioncadherin binding involved in cell-cell adhesion
B0098793cellular_componentpresynapse
B0098794cellular_componentpostsynapse
B0098978cellular_componentglutamatergic synapse
B0180007molecular_functionRNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
B2000806biological_processpositive regulation of termination of RNA polymerase II transcription, poly(A)-coupled
B2001241biological_processpositive regulation of extrinsic apoptotic signaling pathway in absence of ligand
Functional Information from PDB Data
site_idAC1
Number of Residues7
DetailsBINDING SITE FOR RESIDUE MN A 1
ChainResidue
AASP64
AHIS66
AASP92
AMN331
APO4332
AHOH333
AHOH335

site_idAC2
Number of Residues7
DetailsBINDING SITE FOR RESIDUE MN A 331
ChainResidue
AASN124
AHIS173
AHIS248
APO4332
AHOH335
AMN1
AASP92

site_idAC3
Number of Residues13
DetailsBINDING SITE FOR RESIDUE PO4 A 332
ChainResidue
AMN1
AHIS66
AASP92
AARG96
AASN124
AHIS125
AARG221
AHIS248
AMN331
AHOH333
AHOH335
AHOH507
AHOH510

site_idAC4
Number of Residues7
DetailsBINDING SITE FOR RESIDUE MN B 331
ChainResidue
BASP64
BHIS66
BASP92
BMN332
BPO4333
BHOH337
BHOH338

site_idAC5
Number of Residues7
DetailsBINDING SITE FOR RESIDUE MN B 332
ChainResidue
BASP92
BASN124
BHIS173
BHIS248
BMN331
BPO4333
BHOH338

site_idAC6
Number of Residues15
DetailsBINDING SITE FOR RESIDUE PO4 B 333
ChainResidue
BHIS66
BASP92
BARG96
BASN124
BHIS125
BARG221
BHIS248
BTYR272
BMN331
BMN332
BHOH337
BHOH338
BHOH513
BHOH515
BHOH516

site_idAC7
Number of Residues6
DetailsBINDING SITE FOR RESIDUE GOL B 1
ChainResidue
ALYS26
BGLY14
BARG15
BGLU18
BHOH336
BHOH341

site_idAC8
Number of Residues2
DetailsBINDING SITE FOR RESIDUE GOL B 334
ChainResidue
BLYS260
BHOH432

site_idAC9
Number of Residues7
DetailsBINDING SITE FOR RESIDUE GOL B 335
ChainResidue
BCYS127
BSER129
BILE130
BVAL195
BASP197
BTRP206
BHOH422

Functional Information from PROSITE/UniProt
site_idPS00125
Number of Residues6
DetailsSER_THR_PHOSPHATASE Serine/threonine specific protein phosphatases signature. LRGNHE
ChainResidueDetails
ALEU121-GLU126

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsActive site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"P36873","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"30100357","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35830882","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35831509","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36175670","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39446389","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6CZO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7TVF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7TXH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UPI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SW5","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine; by PKA","evidences":[{"source":"PubMed","id":"10504266","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

242500

PDB entries from 2025-10-01

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