3HUM
Crystal structure of Penicillin binding protein 4 from Staphylococcus aureus COL in complex with Cefotaxime
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Penicillin-binding protein 4 | polymer | 453 | 50678.9 | 2 | UniProt (Q5HI26) Pfam (PF00144) Pfam (PF00768) Pfam (PF09211) UniProt (by SIFTS) (A0A0H2WY27) In PDB | Staphylococcus aureus | |
2 | A, B | (2R)-2-[(1R)-1-({[(2R)-2-amino-2,3-dihydro-1,3-thiazol-4-yl](methoxyimino)acetyl}amino)-2-oxoethyl]-5-methyl-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid | non-polymer | 401.5 | 2 | Chemie (CEW) | |||
3 | water | water | 18.0 | 170 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 431 (UniProt: Q5HI26)
PDB | External Database | Details |
---|---|---|
Met -21 | - | expression tag |
Gly -20 | - | expression tag |
Ser -19 | - | expression tag |
Ser -18 | - | expression tag |
His -17 | - | expression tag |
His -16 | - | expression tag |
His -15 | - | expression tag |
His -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
Ser -11 | - | expression tag |
Ser -10 | - | expression tag |
Gly -9 | - | expression tag |
Leu -8 | - | expression tag |
Val -7 | - | expression tag |
Pro -6 | - | expression tag |
Arg -5 | - | expression tag |
Gly -4 | - | expression tag |
Ser -3 | - | expression tag |
His -2 | - | expression tag |
Met -1 | - | expression tag |
Ala 0 | - | expression tag |
Ser 189 | Thr 189 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 101357.9 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 802.9 | |
All* | Total formula weight | 102160.8 |