3HMX
Crystal structure of ustekinumab FAB/IL-12 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Interleukin-12 subunit beta | polymer | 306 | 34739.9 | 1 | UniProt (P29460) Pfam (PF10420) In PDB | Homo sapiens (human) | IL-12B, IL-12 subunit p40, Cytotoxic lymphocyte maturation factor 40 kDa subunit, CLMF p40, NK cell stimulatory factor chain 2, NKSF2 |
| 2 | B | Interleukin-12 subunit alpha | polymer | 197 | 22568.2 | 1 | UniProt (P29459) Pfam (PF03039) In PDB | Homo sapiens (human) | IL-12A, IL-12 subunit p35, Cytotoxic lymphocyte maturation factor 35 kDa subunit, CLMF p35, NK cell stimulatory factor chain 1, NKSF1 |
| 3 | L | USTEKINUMAB FAB LIGHT CHAIN | polymer | 214 | 23475.0 | 1 | Homo sapiens (human) | ||
| 4 | H | USTEKINUMAB FAB HEAVY CHAIN | polymer | 226 | 24361.5 | 1 | Homo sapiens (human) | ||
| 5 | C | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G22768VO) | |||
| 6 | water | water | 18.0 | 44 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 105144.5 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 910.8 | |
| All* | Total formula weight | 106055.4 |
