3HKV

Human poly(ADP-ribose) polymerase 10, catalytic fragment in complex with an inhibitor 3-aminobenzamide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Poly [ADP-ribose] polymerase 10	polymer	217	24480.7	2	UniProt (Q53GL7) Pfam (PF00644)	Homo sapiens (human)	PARP-10
2	C, D, E (A)	PHOSPHATE ION	non-polymer		95.0	3	Chemie (PO4)
3	F, H (A, B)	SODIUM ION	non-polymer		23.0	2	Chemie (NA)
4	G, I (A, B)	3-aminobenzamide	non-polymer		136.2	2	Chemie (3AB)
5	J, K (A, B)	water	water		18.0	183	Chemie (HOH)

Sequence modifications

A, B: 809 - 1017 (UniProt: Q53GL7)

PDB	External Database	Details
Met 808	-	expression tag
Lys 922	Arg 922	engineered mutation
Met 979	Val 979	engineered mutation
Ala 1018	-	expression tag
His 1019	-	expression tag
His 1020	-	expression tag
His 1021	-	expression tag
His 1022	-	expression tag
His 1023	-	expression tag
His 1024	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	48961.4
Non-Polymers*	Number of molecules	7
	Total formula weight	603.2
All*	Total formula weight	49564.6

*Water molecules are not included.