3H98

Crystal structure of HCV NS5b 1b with (1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl) azolo[1,5-a]pyrimidine derivative

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	RNA-directed RNA polymerase	polymer	576	64176.7	2	UniProt (P26663) Pfam (PF00998) In PDB	Hepatitis C virus (isolate BK) (HCV)	NS5B, p68
2	A, B	N-{3-[5-hydroxy-8-(3-methylbutyl)-7-oxo-7,8-dihydroimidazo[1,2-a]pyrimidin-6-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl}methanesulfonamide	non-polymer		494.5	2	Chemie (B5P)
3	A, B	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
4		water	water		18.0	834	Chemie (HOH)

Sequence modifications

A, B: 2 - 570 (UniProt: P26663)

PDB	External Database	Details
Met -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
His 1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	128353.3
Non-Polymers*	Number of molecules	4
	Total formula weight	1173.3
All*	Total formula weight	129526.6

*Water molecules are not included.