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3H98

Crystal structure of HCV NS5b 1b with (1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl) azolo[1,5-a]pyrimidine derivative

Functional Information from GO Data
ChainGOidnamespacecontents
A0003723molecular_functionRNA binding
A0003968molecular_functionRNA-directed RNA polymerase activity
A0039694biological_processviral RNA genome replication
B0003723molecular_functionRNA binding
B0003968molecular_functionRNA-directed RNA polymerase activity
B0039694biological_processviral RNA genome replication
Functional Information from PDB Data
site_idAC1
Number of Residues16
DetailsBINDING SITE FOR RESIDUE B5P A 571
ChainResidue
APHE193
AMET414
ATYR415
ATYR448
AGLY449
ASER556
AHOH657
AHOH721
ASER288
AASN291
AASN316
AGLY317
AASP318
ACYS366
ASER368
ALEU384

site_idAC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE GOL A 572
ChainResidue
AARG386
ATHR390
AHOH927

site_idAC3
Number of Residues14
DetailsBINDING SITE FOR RESIDUE B5P B 571
ChainResidue
BPHE193
BASN291
BASN316
BGLY317
BASP318
BCYS366
BLEU384
BMET414
BTYR415
BTYR448
BGLY449
BSER556
BHOH644
BHOH675

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE GOL B 572
ChainResidue
BSER367
BARG386
BTHR390
BARG394
BHOH958

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues236
DetailsDomain: {"description":"RdRp catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU00539","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"10557268","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"11884572","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine; by host","evidences":[{"source":"UniProtKB","id":"P26662","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

240971

PDB entries from 2025-08-27

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