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3H6V

Crystal structure of the iGluR2 ligand-binding core (S1S2J-N754S) in complex with glutamate and NS5206 at 2.10 A resolution

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BGlutamate receptor 2polymer26329194.72UniProt (P19491)
Pfam (PF10613)
Pfam (PF00060)
Pfam (PF00497)
In PDB
Rattus norvegicus (rat)GluR-2, GluR-B, GluR-K2, Glutamate receptor ionotropic, AMPA 2, AMPA-selective glutamate receptor 2
2A, BGLUTAMIC ACIDnon-polymer147.12Chemie (GLU)
3A, B(3R)-3-cyclopentyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2-benzothiazine 1,1-dioxidenon-polymer413.62Chemie (NS6)
4A, BGLYCEROLnon-polymer92.12Chemie (GOL)
5A, BSULFATE IONnon-polymer96.17Chemie (SO4)
6BDIMETHYL SULFOXIDEnon-polymer78.11Chemie (DMS)
7waterwater18.0659Chemie (HOH)
Sequence modifications
A, B: 3 - 117 (UniProt: P19491)
PDBExternal DatabaseDetails
Gly 1-expression tag
Ala 2-expression tag
A, B: 120 - 263 (UniProt: P19491)
PDBExternal DatabaseDetails
Gly 118-linker
Thr 119-linker
Ser 242Asn 775engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight58389.3
Non-Polymers*Number of molecules14
Total formula weight2056.1
All*Total formula weight60445.4
*Water molecules are not included.

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PDB entries from 2024-06-12

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