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3H6V

Crystal structure of the iGluR2 ligand-binding core (S1S2J-N754S) in complex with glutamate and NS5206 at 2.10 A resolution

Functional Information from GO Data
ChainGOidnamespacecontents
A0015276molecular_functionligand-gated monoatomic ion channel activity
A0016020cellular_componentmembrane
B0015276molecular_functionligand-gated monoatomic ion channel activity
B0016020cellular_componentmembrane
Functional Information from PDB Data
site_idAC1
Number of Residues13
DetailsBINDING SITE FOR RESIDUE GLU A 264
ChainResidue
ATYR61
AGLU193
AHOH287
AHOH310
AHOH322
APRO89
ALEU90
ATHR91
AARG96
ALEU138
AGLY141
ASER142
ATHR143

site_idAC2
Number of Residues14
DetailsBINDING SITE FOR RESIDUE NS6 A 265
ChainResidue
APRO105
AMET107
ASER108
ASER242
ALEU247
AASP248
ALYS251
AHOH299
AHOH319
AHOH481
AHOH655
BILE92
BSER217
BLYS218

site_idAC3
Number of Residues3
DetailsBINDING SITE FOR RESIDUE GOL A 266
ChainResidue
AHIS46
ALYS240
AGLN244

site_idAC4
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 A 267
ChainResidue
ASER140
ALYS144
AARG148
AHOH344
AHOH362
AHOH363
AHOH459

site_idAC5
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 A 268
ChainResidue
AARG148
ATRP159
AARG163

site_idAC6
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 A 269
ChainResidue
ALYS82
ALYS116
AHOH558

site_idAC7
Number of Residues12
DetailsBINDING SITE FOR RESIDUE GLU B 264
ChainResidue
BTYR61
BPRO89
BLEU90
BTHR91
BARG96
BGLY141
BSER142
BTHR143
BGLU193
BHOH283
BHOH312
BHOH380

site_idAC8
Number of Residues13
DetailsBINDING SITE FOR RESIDUE NS6 B 265
ChainResidue
AILE92
ASER217
ALYS218
AHOH634
BPRO105
BMET107
BSER108
BSER242
BASP248
BLYS251
BHOH282
BHOH423
BHOH426

site_idAC9
Number of Residues2
DetailsBINDING SITE FOR RESIDUE DMS B 266
ChainResidue
BARG148
BARG163

site_idBC1
Number of Residues7
DetailsBINDING SITE FOR RESIDUE GOL B 267
ChainResidue
AHOH445
BMET19
BLYS20
BLYS21
BASN22
BHIS23
BHOH456

site_idBC2
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 B 268
ChainResidue
BASP139
BSER140
BLYS144
BARG148
BHOH310
BHOH346
BHOH461

site_idBC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 B 269
ChainResidue
ALYS183
AHOH347
BARG31
BHOH308
BHOH339
BHOH348

site_idBC4
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 B 270
ChainResidue
BSER194
BGLU198
BASN214

site_idBC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 B 271
ChainResidue
BHIS46
BLYS240
BGLN244
BHOH450
BHOH583
BHOH649

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues12
DetailsBINDING: BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO
ChainResidueDetails
APRO89
AARG96
ASER142
ATHR143
BSER142
BTHR143
BGLU193
BPRO89
BTHR91
BARG96
ATHR91
AGLU193

site_idSWS_FT_FI2
Number of Residues6
DetailsSITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405
ChainResidueDetails
ALYS240
BARG64
BARG148
BLYS240
AARG64
AARG148

site_idSWS_FT_FI3
Number of Residues2
DetailsSITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405
ChainResidueDetails
AILE121
BILE121

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293
ChainResidueDetails
ASER150
BSER150

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293
ChainResidueDetails
ASER184
BSER184

site_idSWS_FT_FI6
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN3
BASN3

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PDB entries from 2024-06-12

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