3H42

Crystal structure of PCSK9 in complex with Fab from LDLR competitive antibody

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Proprotein convertase subtilisin/kexin type 9	polymer	126	14107.8	1	UniProt (Q8NBP7) Pfam (PF05922)	Homo sapiens (human)	Proprotein convertase PC9, Subtilisin/kexin-like protease PC9, Neural apoptosis-regulated convertase 1, NARC-1
2	B (B)	Proprotein convertase subtilisin/kexin type 9	polymer	540	57328.6	1	UniProt (Q8NBP7) Pfam (PF00082) Pfam (PF18459) Pfam (PF18464) Pfam (PF18463)	Homo sapiens (human)	Proprotein convertase PC9, Subtilisin/kexin-like protease PC9, Neural apoptosis-regulated convertase 1, NARC-1
3	C (L)	Fab from LDLR competitive antibody: Light chain	polymer	217	22626.9	1		Homo sapiens (human)
4	D (H)	Fab from LDLR competitive antibody: Heavy chain	polymer	238	25489.3	1		Homo sapiens (human)
5	E (B)	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
6	F, G, H, I (A, B, L, H)	water	water		18.0	568	Chemie (HOH)

Sequence modifications

A: 31 - 152 (UniProt: Q8NBP7)

PDB	External Database	Details
Gly 27	-	expression tag
Ala 28	-	expression tag
Met 29	-	expression tag
Gly 30	-	expression tag

B: 153 - 692 (UniProt: Q8NBP7)

PDB	External Database	Details
Ala 533	Asn 533	engineered mutation
Gly 620	Glu 620	SEE REMARK 999

H: 1 - 232 (PDB: 3H42)

PDB	External Database	Details
His 233	-	expression tag
His 234	-	expression tag
His 235	-	expression tag
His 236	-	expression tag
His 237	-	expression tag
His 238	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	119552.6
Non-Polymers*	Number of molecules	1
	Total formula weight	23.0
All*	Total formula weight	119575.6

*Water molecules are not included.