3H42

Crystal structure of PCSK9 in complex with Fab from LDLR competitive antibody

Summary for 3H42

• Entry DOI: 10.2210/pdb3h42/pdb
• Descriptor: Proprotein convertase subtilisin/kexin type 9, Fab from LDLR competitive antibody: Light chain, Fab from LDLR competitive antibody: Heavy chain, ... (6 entities in total)
• Functional Keywords: hydrolase, protein fab complex, autocatalytic cleavage, cholesterol metabolism, disease mutation, disulfide bond, glycoprotein, lipid metabolism, phosphoprotein, protease, secreted, serine protease, steroid metabolism, zymogen, hydrolase-immune system complex, hydrolase/immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: Q8NBP7 Q8NBP7
• Total number of polymer chains: 4
• Total formula weight: 119575.64

Authors

Piper, D.E.,Walker, N.P.C.,Romanow, W.G.,Thibault, S.T.,Tsai, M.M.,Yang, E. (deposition date: 2009-04-17, release date: 2009-05-05, Last modification date: 2023-09-06)

• Primary citation: Chan, J.C.,Piper, D.E.,Cao, Q.,Liu, D.,King, C.,Wang, W.,Tang, J.,Liu, Q.,Higbee, J.,Xia, Z.,Di, Y.,Shetterly, S.,Arimura, Z.,Salomonis, H.,Romanow, W.G.,Thibault, S.T.,Zhang, R.,Cao, P.,Yang, X.P.,Yu, T.,Lu, M.,Retter, M.W.,Kwon, G.,Henne, K.,Pan, O.,Tsai, M.M.,Fuchslocher, B.,Yang, E.,Zhou, L.,Lee, K.J.,Daris, M.,Sheng, J.,Wang, Y.,Shen, W.D.,Yeh, W.C.,Emery, M.,Walker, N.P.,Shan, B.,Schwarz, M.,Jackson, S.M.; From the Cover: A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates.; Proc.Natl.Acad.Sci.USA, 106:9820-9825, 2009; PubMed: 19443683; DOI: 10.1073/pnas.0903849106

Experimental method

X-RAY DIFFRACTION (2.3 Å)