3H3G

Crystal structure of the extracellular domain of the human parathyroid hormone receptor (PTH1R) in complex with parathyroid hormone-related protein (PTHrP)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Fusion protein of Maltose-binding periplasmic domain and human parathyroid hormone receptor extracellular domain	polymer	539	60297.9	1	UniProt (P0AEX9) UniProt (Q03431) Pfam (PF01547) Pfam (PF02793) In PDB	Escherichia coli	Maltodextrin-binding protein, MMBP, PTH/PTHr receptor, PTH/PTHrP type I receptor
2	B	Parathyroid hormone-related protein	polymer	24	2764.2	1	UniProt (P12272) In PDB		PTH-rP, PTHrP, PLP, Osteostatin
3	C	alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose	branched		342.3	1	In PDB BIRD (PRD_900001) GlyTouCan (G07411ON)		alpha-maltose
4		water	water		18.0	237	Chemie (HOH)

Sequence modifications

A: -344 - 22 (UniProt: P0AEX9)

PDB	External Database	Details
Met -345	-	initiating methionine
Asn 23	-	linker
Ala 24	-	linker
Ala 25	-	linker
Ala 26	-	linker
Glu 27	-	linker
Phe 28	-	linker

A: 29 - 187 (UniProt: Q03431)

PDB	External Database	Details
His 188	-	expression tag
His 189	-	expression tag
His 190	-	expression tag
His 191	-	expression tag
His 192	-	expression tag
His 193	-	expression tag

B: 12 - 34 (UniProt: P12272)

PDB	External Database	Details
Nh2 35	-	amidation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	63062.2
Branched	Number of molecules	1
	Total formula weight	342.3
All*	Total formula weight	63404.5

*Water molecules are not included.