3GUT

Crystal structure of a higher-order complex of p50:RelA bound to the HIV-1 LTR

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E, G	Transcription factor p65	polymer	273	30984.0	4	UniProt (Q04206) Pfam (PF00554) Pfam (PF16179) In PDB	Homo sapiens (human)	Nuclear factor NF-kappa-B p65 subunit
2	B, D, F, H	Nuclear factor NF-kappa-B p105 subunit	polymer	312	34924.9	4	UniProt (P19838) Pfam (PF00554) Pfam (PF16179) In PDB	Homo sapiens (human)	DNA-binding factor KBF1, EBP-1, Nuclear factor NF-kappa-B p50 subunit
3	X, I	HIV-LTR Core Forward Strand	polymer	26	7995.1	2		Human immunodeficiency virus (virus)
4	Y, J	HIV-LTR Core Reverse Strand	polymer	26	7982.2	2		Human immunodeficiency virus (virus)

Sequence modifications

A, C, E, G: 20 - 291 (UniProt: Q04206)

PDB	External Database	Details
Ala 19	-	expression tag
Tyr 99	Phe 99	SEE REMARK 999
Asp 103	Glu 103	SEE REMARK 999
Ser 109	Cys 109	SEE REMARK 999
His 142	Gln 142	SEE REMARK 999
Ala 169	Ser 169	SEE REMARK 999
Leu 174	Arg 174	SEE REMARK 999
Thr 176	Pro 176	SEE REMARK 999

B, D, F, H: 339 - 650 (UniProt: P19838)

PDB	External Database	Details
Val 420	Ile 122	SEE REMARK 999
Ser 471	Pro 173	SEE REMARK 999
Thr 487	Gly 189	SEE REMARK 999
Ile 493	Leu 195	SEE REMARK 999
Val 499	Leu 201	SEE REMARK 999
Val 619	Ile 321	SEE REMARK 999

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	295590.3
All*	Total formula weight	295590.3

*Water molecules are not included.