3GUG
Crystal structure of AKR1C1 L308V mutant in complex with NADP and 3,5-dichlorosalicylic acid
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Aldo-keto reductase family 1 member C1 | polymer | 323 | 36825.3 | 1 | UniProt (Q04828) Pfam (PF00248) In PDB | Homo sapiens (human) | 20-alpha-hydroxysteroid dehydrogenase, 20-alpha-HSD |
| 2 | A | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 1 | Chemie (NAP) | |||
| 3 | A | 3,5-dichloro-2-hydroxybenzoic acid | non-polymer | 207.0 | 1 | Chemie (C2U) | |||
| 4 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 5 | water | water | 18.0 | 318 | Chemie (HOH) |
Sequence modifications
A: 1 - 323 (UniProt: Q04828)
| PDB | External Database | Details |
|---|---|---|
| Val 308 | Leu 308 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36825.3 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1015.8 | |
| All* | Total formula weight | 37841.1 |
