3GRB
Crystal structure of the F87M/L110M mutant of human transthyretin at pH 6.5
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D (A, B, D, C) | Transthyretin | polymer | 127 | 13779.4 | 4 | UniProt (P02766) Pfam (PF00576) | Homo sapiens (Human) | Prealbumin, TBPA, TTR, ATTR |
2 | BA, E, F, J, K... (C, A, B, D) | ZINC ION | non-polymer | 65.4 | 12 | Chemie (ZN) | |||
3 | AA, G, H, I, N... (C, A, B, D) | GLYCEROL | non-polymer | 92.1 | 7 | Chemie (GOL) | |||
4 | CA, O, R, S, Y... (C, B, D) | ACETATE ION | non-polymer | 59.0 | 6 | Chemie (ACT) | |||
5 | DA, EA, FA, GA (A, B, D, C) | water | water | 18.0 | 285 | Chemie (HOH) |
Sequence modifications
A, B, D, C: 1 - 127 (UniProt: P02766)
PDB | External Database | Details |
---|---|---|
Met 87 | Phe 107 | engineered mutation |
Met 110 | Leu 130 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 55117.7 | |
Non-Polymers* | Number of molecules | 25 |
Total formula weight | 1783.8 | |
All* | Total formula weight | 56901.5 |