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3GRB

Crystal structure of the F87M/L110M mutant of human transthyretin at pH 6.5

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, C, D
(A, B, D, C)
Transthyretinpolymer12713779.44UniProt (P02766)
Pfam (PF00576)
Homo sapiens (Human)Prealbumin, TBPA, TTR, ATTR
2BA, E, F, J, K...
(C, A, B, D)
ZINC IONnon-polymer65.412Chemie (ZN)
3AA, G, H, I, N...
(C, A, B, D)
GLYCEROLnon-polymer92.17Chemie (GOL)
4CA, O, R, S, Y...
(C, B, D)
ACETATE IONnon-polymer59.06Chemie (ACT)
5DA, EA, FA, GA
(A, B, D, C)
waterwater18.0285Chemie (HOH)
Sequence modifications
A, B, D, C: 1 - 127 (UniProt: P02766)
PDBExternal DatabaseDetails
Met 87Phe 107engineered mutation
Met 110Leu 130engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight55117.7
Non-Polymers*Number of molecules25
Total formula weight1783.8
All*Total formula weight56901.5
*Water molecules are not included.

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PDB entries from 2024-11-06

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