Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005179 | molecular_function | hormone activity |
A | 0005515 | molecular_function | protein binding |
A | 0005576 | cellular_component | extracellular region |
A | 0005615 | cellular_component | extracellular space |
A | 0005737 | cellular_component | cytoplasm |
A | 0006144 | biological_process | purine nucleobase metabolic process |
A | 0007165 | biological_process | signal transduction |
A | 0035578 | cellular_component | azurophil granule lumen |
A | 0042802 | molecular_function | identical protein binding |
A | 0070062 | cellular_component | extracellular exosome |
A | 0070324 | molecular_function | thyroid hormone binding |
B | 0005179 | molecular_function | hormone activity |
B | 0005515 | molecular_function | protein binding |
B | 0005576 | cellular_component | extracellular region |
B | 0005615 | cellular_component | extracellular space |
B | 0005737 | cellular_component | cytoplasm |
B | 0006144 | biological_process | purine nucleobase metabolic process |
B | 0007165 | biological_process | signal transduction |
B | 0035578 | cellular_component | azurophil granule lumen |
B | 0042802 | molecular_function | identical protein binding |
B | 0070062 | cellular_component | extracellular exosome |
B | 0070324 | molecular_function | thyroid hormone binding |
C | 0005179 | molecular_function | hormone activity |
C | 0005515 | molecular_function | protein binding |
C | 0005576 | cellular_component | extracellular region |
C | 0005615 | cellular_component | extracellular space |
C | 0005737 | cellular_component | cytoplasm |
C | 0006144 | biological_process | purine nucleobase metabolic process |
C | 0007165 | biological_process | signal transduction |
C | 0035578 | cellular_component | azurophil granule lumen |
C | 0042802 | molecular_function | identical protein binding |
C | 0070062 | cellular_component | extracellular exosome |
C | 0070324 | molecular_function | thyroid hormone binding |
D | 0005179 | molecular_function | hormone activity |
D | 0005515 | molecular_function | protein binding |
D | 0005576 | cellular_component | extracellular region |
D | 0005615 | cellular_component | extracellular space |
D | 0005737 | cellular_component | cytoplasm |
D | 0006144 | biological_process | purine nucleobase metabolic process |
D | 0007165 | biological_process | signal transduction |
D | 0035578 | cellular_component | azurophil granule lumen |
D | 0042802 | molecular_function | identical protein binding |
D | 0070062 | cellular_component | extracellular exosome |
D | 0070324 | molecular_function | thyroid hormone binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A 129 |
Chain | Residue |
A | CYS10 |
A | HIS56 |
A | HOH153 |
A | HOH308 |
site_id | AC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A 130 |
Chain | Residue |
A | HIS88 |
A | HIS90 |
A | GLU92 |
A | HOH311 |
site_id | AC3 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE GOL A 131 |
Chain | Residue |
A | ALA36 |
A | ALA37 |
A | ARG34 |
site_id | AC4 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE GOL A 132 |
Chain | Residue |
A | ALA19 |
A | MET110 |
A | LEU111 |
A | SER112 |
A | SER115 |
A | SER117 |
D | ALA19 |
D | MET110 |
D | LEU111 |
D | SER112 |
D | SER115 |
site_id | AC5 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL A 133 |
Chain | Residue |
A | LYS70 |
A | GLU72 |
A | GLU92 |
B | TRP41 |
B | LYS70 |
B | VAL94 |
B | HOH220 |
site_id | AC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A 134 |
Chain | Residue |
A | HIS31 |
A | GLU72 |
A | ASP74 |
A | HOH325 |
site_id | AC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN B 128 |
Chain | Residue |
B | CYS10 |
B | HIS56 |
B | HOH312 |
B | HOH313 |
site_id | AC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN B 129 |
Chain | Residue |
B | HIS31 |
B | GLU72 |
B | ASP74 |
B | HOH322 |
site_id | AC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN B 130 |
Chain | Residue |
B | HIS88 |
B | HIS90 |
B | GLU92 |
B | HOH134 |
site_id | BC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE GOL B 131 |
Chain | Residue |
B | HIS31 |
B | SER46 |
B | GLY47 |
site_id | BC2 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE ACT B 132 |
Chain | Residue |
B | THR75 |
B | TRP79 |
B | PRO86 |
B | MET87 |
B | HIS88 |
B | HIS90 |
B | ALA91 |
B | SER112 |
B | PRO113 |
B | SER115 |
B | TYR116 |
site_id | BC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN D 128 |
Chain | Residue |
D | CYS10 |
D | HIS56 |
D | HOH136 |
D | HOH315 |
site_id | BC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN D 129 |
Chain | Residue |
D | HIS88 |
D | HIS90 |
D | GLU92 |
D | HOH317 |
site_id | BC5 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE ACT D 130 |
Chain | Residue |
D | THR75 |
D | TRP79 |
D | PRO86 |
D | MET87 |
D | HIS88 |
D | HIS90 |
D | ALA91 |
D | SER112 |
D | PRO113 |
D | SER115 |
D | TYR116 |
D | HOH159 |
site_id | BC6 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE ACT D 131 |
site_id | BC7 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL D 132 |
Chain | Residue |
C | TRP41 |
C | LYS70 |
C | VAL94 |
D | TRP41 |
D | LYS70 |
D | GLU72 |
D | GLU92 |
site_id | BC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN D 133 |
Chain | Residue |
D | HIS31 |
D | GLU72 |
D | ASP74 |
D | HOH326 |
site_id | BC9 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE GOL D 134 |
site_id | CC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN C 128 |
Chain | Residue |
C | CYS10 |
C | HIS56 |
C | HOH318 |
C | HOH319 |
site_id | CC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN C 129 |
Chain | Residue |
C | HIS90 |
C | GLU92 |
C | HOH137 |
C | HIS88 |
site_id | CC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE ACT C 130 |
Chain | Residue |
C | THR96 |
C | ASP99 |
C | TYR105 |
D | MET87 |
D | TYR114 |
D | HOH165 |
site_id | CC4 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE ACT C 131 |
Chain | Residue |
C | THR75 |
C | TRP79 |
C | PRO86 |
C | MET87 |
C | HIS88 |
C | HIS90 |
C | ALA91 |
C | SER112 |
C | PRO113 |
C | SER115 |
C | TYR116 |
site_id | CC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE GOL C 132 |
Chain | Residue |
C | HIS31 |
C | SER46 |
C | GLY47 |
site_id | CC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN C 133 |
Chain | Residue |
C | HIS31 |
C | GLU72 |
C | ASP74 |
C | HOH323 |
site_id | CC7 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE ACT C 134 |
Chain | Residue |
B | MET110 |
B | SER115 |
B | SER117 |
C | SER115 |
C | TYR116 |
C | SER117 |
C | HOH171 |
C | HOH176 |
Functional Information from PROSITE/UniProt
site_id | PS00768 |
Number of Residues | 16 |
Details | TRANSTHYRETIN_1 Transthyretin signature 1. KVLDavrGsPAinVaV |
Chain | Residue | Details |
A | LYS15-VAL30 | |
site_id | PS00769 |
Number of Residues | 13 |
Details | TRANSTHYRETIN_2 Transthyretin signature 2. YTIAamLSPYSYS |
Chain | Residue | Details |
A | TYR105-SER117 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | LYS15 | |
C | LYS15 | |
C | GLU54 | |
C | SER117 | |
A | GLU54 | |
A | SER117 | |
B | LYS15 | |
B | GLU54 | |
B | SER117 | |
D | LYS15 | |
D | GLU54 | |
D | SER117 | |
Chain | Residue | Details |
A | CYS10 | |
B | CYS10 | |
D | CYS10 | |
C | CYS10 | |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | MOD_RES: 4-carboxyglutamate; in a patient with Moyamoya disease => ECO:0000269|PubMed:18221012 |
Chain | Residue | Details |
A | GLU42 | |
B | GLU42 | |
D | GLU42 | |
C | GLU42 | |
Chain | Residue | Details |
A | SER52 | |
B | SER52 | |
D | SER52 | |
C | SER52 | |
Chain | Residue | Details |
A | ASN98 | |
B | ASN98 | |
D | ASN98 | |
C | ASN98 | |