3GQL
Crystal Structure of activated receptor tyrosine kinase in complex with substrates
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Basic fibroblast growth factor receptor 1 | polymer | 326 | 37290.9 | 3 | UniProt (P11362) Pfam (PF07714) | Homo sapiens (human) | FGFR-1, bFGF-R, Fms-like tyrosine kinase 2, c-fgr |
| 2 | D, E, F (A, B, C) | (E)-[4-(3,5-difluorophenyl)-3H-pyrrolo[2,3-b]pyridin-3-ylidene](3-methoxyphenyl)methanol | non-polymer | 364.3 | 3 | Chemie (GQL) | |||
| 3 | G, H, I (A, B, C) | water | water | 18.0 | 187 | Chemie (HOH) |
Sequence modifications
A, B, C: 459 - 774 (UniProt: P11362)
| PDB | External Database | Details |
|---|---|---|
| Met 449 | - | expression tag |
| Gly 450 | - | expression tag |
| His 451 | - | expression tag |
| His 452 | - | expression tag |
| His 453 | - | expression tag |
| His 454 | - | expression tag |
| His 455 | - | expression tag |
| His 456 | - | expression tag |
| Met 457 | - | expression tag |
| Ala 488 | Cys 488 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 111872.6 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1093.0 | |
| All* | Total formula weight | 112965.6 |
