3GQL

Crystal Structure of activated receptor tyrosine kinase in complex with substrates

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C	Basic fibroblast growth factor receptor 1	polymer	326	37290.9	3	UniProt (P11362) Pfam (PF07714) In PDB	Homo sapiens (human)	FGFR-1, bFGF-R, Fms-like tyrosine kinase 2, c-fgr
2	A, B, C	(E)-[4-(3,5-difluorophenyl)-3H-pyrrolo[2,3-b]pyridin-3-ylidene](3-methoxyphenyl)methanol	non-polymer		364.3	3	Chemie (GQL)
3		water	water		18.0	187	Chemie (HOH)

Sequence modifications

A, B, C: 459 - 774 (UniProt: P11362)

PDB	External Database	Details
Met 449	-	expression tag
Gly 450	-	expression tag
His 451	-	expression tag
His 452	-	expression tag
His 453	-	expression tag
His 454	-	expression tag
His 455	-	expression tag
His 456	-	expression tag
Met 457	-	expression tag
Ala 488	Cys 488	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	111872.6
Non-Polymers*	Number of molecules	3
	Total formula weight	1093.0
All*	Total formula weight	112965.6

*Water molecules are not included.