3GOV

Crystal structure of the catalytic region of human MASP-1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	MASP-1	polymer	155	17508.2	1	UniProt (P48740) Pfam (PF00084)	Homo sapiens (human)	Ra-reactive factor serine protease p100, RaRF, Mannan-binding lectin serine protease 1, Mannose-binding protein-associated serine protease, MASP-1, Serine protease 5, Complement-activating component of Ra-reactive factor heavy chain, Complement-activating component of Ra-reactive factor light chain
2	B (B)	MASP-1	polymer	251	28028.9	1	UniProt (P48740) Pfam (PF00089)	Homo sapiens (human)	Ra-reactive factor serine protease p100, RaRF, Mannan-binding lectin serine protease 1, Mannose-binding protein-associated serine protease, MASP-1, Serine protease 5, Complement-activating component of Ra-reactive factor heavy chain, Complement-activating component of Ra-reactive factor light chain
3	C, D (A, B)	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
4	E, F (A, B)	water	water		18.0	90	Chemie (HOH)

Sequence modifications

A: 298 - 448 (UniProt: P48740)

PDB	External Database	Details
Ala 294	-	expression tag
Ser 295	-	expression tag
Met 296	-	expression tag
Thr 297	-	expression tag

B: 449 - 699 (UniProt: P48740)

PDB	External Database	Details
Lys 499	Glu 499	SEE REMARK 999

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	45537.1
Non-Polymers*	Number of molecules	2
	Total formula weight	184.2
All*	Total formula weight	45721.3

*Water molecules are not included.