3GJX

Crystal Structure of the Nuclear Export Complex CRM1-Snurportin1-RanGTP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (B, E)	Snurportin-1	polymer	365	41610.9	2	UniProt (O95149) Pfam (PF11538) Pfam (PF21974)	Homo sapiens (Human)	RNA U transporter 1
2	B, E (C, F)	GTP-binding nuclear protein Ran	polymer	216	24441.1	2	UniProt (P62826) Pfam (PF00071)	Homo sapiens (Human)	RanGTP, GTPase Ran, Ras-related nuclear protein, Ras-like protein TC4, Androgen receptor-associated protein 24
3	C, F (A, D)	Exportin-1	polymer	1073	123367.2	2	UniProt (Q6P5F9) Pfam (PF03810) Pfam (PF08389) Pfam (PF18777) Pfam (PF18784) Pfam (PF18787) Pfam (PF08767)	Mus musculus (mouse)	Crm1, Exp1, Chromosome region maintenance 1 protein homolog
4	G, J (B, E)	SODIUM ION	non-polymer		23.0	2	Chemie (NA)
5	H, L (C, F)	GUANOSINE-5'-TRIPHOSPHATE	non-polymer		523.2	2	Chemie (GTP)
6	I, M (C, F)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
7	K (E)	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
8	N, O, P, Q, R... (B, C, A, E, F...)	water	water		18.0	959	Chemie (HOH)

Sequence modifications

B, E: 1 - 360 (UniProt: O95149)

PDB	External Database	Details
Gly -4	-	expression tag
Pro -3	-	expression tag
Leu -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag

C, F: 1 - 216 (UniProt: P62826)

PDB	External Database	Details
Leu 69	Gln 69	engineered mutation

A, D: 1 - 1071 (UniProt: Q6P5F9)

PDB	External Database	Details
Gly -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	378838.6
Non-Polymers*	Number of molecules	7
	Total formula weight	1176.4
All*	Total formula weight	380015.0

*Water molecules are not included.