3GJX
Crystal Structure of the Nuclear Export Complex CRM1-Snurportin1-RanGTP
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | B, E | Snurportin-1 | polymer | 365 | 41610.9 | 2 | UniProt (O95149) Pfam (PF11538) Pfam (PF21974) In PDB | Homo sapiens (Human) | RNA U transporter 1 |
2 | C, F | GTP-binding nuclear protein Ran | polymer | 216 | 24441.1 | 2 | UniProt (P62826) Pfam (PF00071) In PDB | Homo sapiens (Human) | RanGTP, GTPase Ran, Ras-related nuclear protein, Ras-like protein TC4, Androgen receptor-associated protein 24 |
3 | A, D | Exportin-1 | polymer | 1073 | 123367.2 | 2 | UniProt (Q6P5F9) Pfam (PF03810) Pfam (PF08389) Pfam (PF18777) Pfam (PF18784) Pfam (PF18787) Pfam (PF08767) In PDB | Mus musculus (mouse) | Crm1, Exp1, Chromosome region maintenance 1 protein homolog |
4 | B, E | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
5 | C, F | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 2 | Chemie (GTP) | |||
6 | C, F | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
7 | E | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
8 | water | water | 18.0 | 959 | Chemie (HOH) |
Sequence modifications
B, E: 1 - 360 (UniProt: O95149)
C, F: 1 - 216 (UniProt: P62826)
A, D: 1 - 1071 (UniProt: Q6P5F9)
PDB | External Database | Details |
---|---|---|
Gly -4 | - | expression tag |
Pro -3 | - | expression tag |
Leu -2 | - | expression tag |
Gly -1 | - | expression tag |
Ser 0 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Leu 69 | Gln 69 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Gly -1 | - | expression tag |
Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 378838.6 | |
Non-Polymers* | Number of molecules | 7 |
Total formula weight | 1176.4 | |
All* | Total formula weight | 380015.0 |