3GJX
Crystal Structure of the Nuclear Export Complex CRM1-Snurportin1-RanGTP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (B, E) | Snurportin-1 | polymer | 365 | 41610.9 | 2 | UniProt (O95149) Pfam (PF11538) Pfam (PF21974) | Homo sapiens (Human) | RNA U transporter 1 |
| 2 | B, E (C, F) | GTP-binding nuclear protein Ran | polymer | 216 | 24441.1 | 2 | UniProt (P62826) Pfam (PF00071) | Homo sapiens (Human) | RanGTP, GTPase Ran, Ras-related nuclear protein, Ras-like protein TC4, Androgen receptor-associated protein 24 |
| 3 | C, F (A, D) | Exportin-1 | polymer | 1073 | 123367.2 | 2 | UniProt (Q6P5F9) Pfam (PF03810) Pfam (PF08389) Pfam (PF18777) Pfam (PF18784) Pfam (PF18787) Pfam (PF08767) | Mus musculus (mouse) | Crm1, Exp1, Chromosome region maintenance 1 protein homolog |
| 4 | G, J (B, E) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) PubChem (923) | |||
| 5 | H, L (C, F) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 2 | Chemie (GTP) PubChem (177679032) PubChem (135400627) PubChem (135487750) PubChem (136088935) PubChem (136803486) PubChem (135398633) PubChem (135544356) PubChem (135547949) PubChem (135600366) PubChem (135749822) PubChem (136005188) PubChem (136073923) PubChem (136240914) PubChem (136664747) PubChem (136772743) PubChem (136772744) PubChem (136803487) PubChem (137286749) PubChem (164715984) PubChem (171699466) | |||
| 6 | I, M (C, F) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) | |||
| 7 | K (E) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) PubChem (312) | |||
| 8 | N, O, P, Q, R... (B, C, A, E, F...) | water | water | 18.0 | 959 | Chemie (HOH) |
Sequence modifications
B, E: 1 - 360 (UniProt: O95149)
C, F: 1 - 216 (UniProt: P62826)
A, D: 1 - 1071 (UniProt: Q6P5F9)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Pro -3 | - | expression tag |
| Leu -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Leu 69 | Gln 69 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 378838.6 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1176.4 | |
| All* | Total formula weight | 380015.0 |
