Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3GJX

Crystal Structure of the Nuclear Export Complex CRM1-Snurportin1-RanGTP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000054	biological_process	ribosomal subunit export from nucleus
A	0000055	biological_process	ribosomal large subunit export from nucleus
A	0000056	biological_process	ribosomal small subunit export from nucleus
A	0000776	cellular_component	kinetochore
A	0003723	molecular_function	RNA binding
A	0005049	molecular_function	nuclear export signal receptor activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005642	cellular_component	annulate lamellae
A	0005654	cellular_component	nucleoplasm
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006406	biological_process	mRNA export from nucleus
A	0006611	biological_process	protein export from nucleus
A	0006886	biological_process	intracellular protein transport
A	0006913	biological_process	nucleocytoplasmic transport
A	0010824	biological_process	regulation of centrosome duplication
A	0015030	cellular_component	Cajal body
A	0015031	biological_process	protein transport
A	0031267	molecular_function	small GTPase binding
A	0031965	cellular_component	nuclear membrane
A	0032434	biological_process	regulation of proteasomal ubiquitin-dependent protein catabolic process
A	0032991	cellular_component	protein-containing complex
A	0034504	biological_process	protein localization to nucleus
A	0042176	biological_process	regulation of protein catabolic process
A	0042254	biological_process	ribosome biogenesis
A	0043231	cellular_component	intracellular membrane-bounded organelle
A	0046825	biological_process	regulation of protein export from nucleus
A	0051028	biological_process	mRNA transport
A	1990904	cellular_component	ribonucleoprotein complex
B	0000339	molecular_function	RNA cap binding
B	0003723	molecular_function	RNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005643	cellular_component	nuclear pore
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006404	biological_process	RNA import into nucleus
B	0006606	biological_process	protein import into nucleus
B	0042564	cellular_component	NLS-dependent protein nuclear import complex
B	0061015	biological_process	snRNA import into nucleus
B	0061608	molecular_function	nuclear import signal receptor activity
C	0000054	biological_process	ribosomal subunit export from nucleus
C	0000055	biological_process	ribosomal large subunit export from nucleus
C	0000056	biological_process	ribosomal small subunit export from nucleus
C	0000070	biological_process	mitotic sister chromatid segregation
C	0000278	biological_process	mitotic cell cycle
C	0000287	molecular_function	magnesium ion binding
C	0000785	cellular_component	chromatin
C	0001673	cellular_component	male germ cell nucleus
C	0002177	cellular_component	manchette
C	0003682	molecular_function	chromatin binding
C	0003723	molecular_function	RNA binding
C	0003924	molecular_function	GTPase activity
C	0003925	molecular_function	G protein activity
C	0005049	molecular_function	nuclear export signal receptor activity
C	0005515	molecular_function	protein binding
C	0005525	molecular_function	GTP binding
C	0005634	cellular_component	nucleus
C	0005635	cellular_component	nuclear envelope
C	0005643	cellular_component	nuclear pore
C	0005654	cellular_component	nucleoplasm
C	0005730	cellular_component	nucleolus
C	0005737	cellular_component	cytoplasm
C	0005814	cellular_component	centriole
C	0005829	cellular_component	cytosol
C	0006259	biological_process	DNA metabolic process
C	0006606	biological_process	protein import into nucleus
C	0006611	biological_process	protein export from nucleus
C	0006913	biological_process	nucleocytoplasmic transport
C	0007052	biological_process	mitotic spindle organization
C	0007286	biological_process	spermatid development
C	0008104	biological_process	protein localization
C	0014070	biological_process	response to organic cyclic compound
C	0015031	biological_process	protein transport
C	0016020	cellular_component	membrane
C	0016032	biological_process	viral process
C	0016787	molecular_function	hydrolase activity
C	0019003	molecular_function	GDP binding
C	0019904	molecular_function	protein domain specific binding
C	0021766	biological_process	hippocampus development
C	0030036	biological_process	actin cytoskeleton organization
C	0030496	cellular_component	midbody
C	0031503	biological_process	protein-containing complex localization
C	0032092	biological_process	positive regulation of protein binding
C	0032991	cellular_component	protein-containing complex
C	0035281	biological_process	pre-miRNA export from nucleus
C	0036126	cellular_component	sperm flagellum
C	0042307	biological_process	positive regulation of protein import into nucleus
C	0042470	cellular_component	melanosome
C	0042565	cellular_component	RNA nuclear export complex
C	0044877	molecular_function	protein-containing complex binding
C	0045296	molecular_function	cadherin binding
C	0045505	molecular_function	dynein intermediate chain binding
C	0046039	biological_process	GTP metabolic process
C	0046872	molecular_function	metal ion binding
C	0046982	molecular_function	protein heterodimerization activity
C	0051301	biological_process	cell division
C	0055037	cellular_component	recycling endosome
C	0061015	biological_process	snRNA import into nucleus
C	0061676	molecular_function	importin-alpha family protein binding
C	0070062	cellular_component	extracellular exosome
C	0070883	molecular_function	pre-miRNA binding
C	0071389	biological_process	cellular response to mineralocorticoid stimulus
C	0090543	cellular_component	Flemming body
C	1902570	biological_process	protein localization to nucleolus
D	0000054	biological_process	ribosomal subunit export from nucleus
D	0000055	biological_process	ribosomal large subunit export from nucleus
D	0000056	biological_process	ribosomal small subunit export from nucleus
D	0000776	cellular_component	kinetochore
D	0003723	molecular_function	RNA binding
D	0005049	molecular_function	nuclear export signal receptor activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005642	cellular_component	annulate lamellae
D	0005654	cellular_component	nucleoplasm
D	0005730	cellular_component	nucleolus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006406	biological_process	mRNA export from nucleus
D	0006611	biological_process	protein export from nucleus
D	0006886	biological_process	intracellular protein transport
D	0006913	biological_process	nucleocytoplasmic transport
D	0010824	biological_process	regulation of centrosome duplication
D	0015030	cellular_component	Cajal body
D	0015031	biological_process	protein transport
D	0031267	molecular_function	small GTPase binding
D	0031965	cellular_component	nuclear membrane
D	0032434	biological_process	regulation of proteasomal ubiquitin-dependent protein catabolic process
D	0032991	cellular_component	protein-containing complex
D	0034504	biological_process	protein localization to nucleus
D	0042176	biological_process	regulation of protein catabolic process
D	0042254	biological_process	ribosome biogenesis
D	0043231	cellular_component	intracellular membrane-bounded organelle
D	0046825	biological_process	regulation of protein export from nucleus
D	0051028	biological_process	mRNA transport
D	1990904	cellular_component	ribonucleoprotein complex
E	0000339	molecular_function	RNA cap binding
E	0003723	molecular_function	RNA binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005643	cellular_component	nuclear pore
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0006404	biological_process	RNA import into nucleus
E	0006606	biological_process	protein import into nucleus
E	0042564	cellular_component	NLS-dependent protein nuclear import complex
E	0061015	biological_process	snRNA import into nucleus
E	0061608	molecular_function	nuclear import signal receptor activity
F	0000054	biological_process	ribosomal subunit export from nucleus
F	0000055	biological_process	ribosomal large subunit export from nucleus
F	0000056	biological_process	ribosomal small subunit export from nucleus
F	0000070	biological_process	mitotic sister chromatid segregation
F	0000278	biological_process	mitotic cell cycle
F	0000287	molecular_function	magnesium ion binding
F	0000785	cellular_component	chromatin
F	0001673	cellular_component	male germ cell nucleus
F	0002177	cellular_component	manchette
F	0003682	molecular_function	chromatin binding
F	0003723	molecular_function	RNA binding
F	0003924	molecular_function	GTPase activity
F	0003925	molecular_function	G protein activity
F	0005049	molecular_function	nuclear export signal receptor activity
F	0005515	molecular_function	protein binding
F	0005525	molecular_function	GTP binding
F	0005634	cellular_component	nucleus
F	0005635	cellular_component	nuclear envelope
F	0005643	cellular_component	nuclear pore
F	0005654	cellular_component	nucleoplasm
F	0005730	cellular_component	nucleolus
F	0005737	cellular_component	cytoplasm
F	0005814	cellular_component	centriole
F	0005829	cellular_component	cytosol
F	0006259	biological_process	DNA metabolic process
F	0006606	biological_process	protein import into nucleus
F	0006611	biological_process	protein export from nucleus
F	0006913	biological_process	nucleocytoplasmic transport
F	0007052	biological_process	mitotic spindle organization
F	0007286	biological_process	spermatid development
F	0008104	biological_process	protein localization
F	0014070	biological_process	response to organic cyclic compound
F	0015031	biological_process	protein transport
F	0016020	cellular_component	membrane
F	0016032	biological_process	viral process
F	0016787	molecular_function	hydrolase activity
F	0019003	molecular_function	GDP binding
F	0019904	molecular_function	protein domain specific binding
F	0021766	biological_process	hippocampus development
F	0030036	biological_process	actin cytoskeleton organization
F	0030496	cellular_component	midbody
F	0031503	biological_process	protein-containing complex localization
F	0032092	biological_process	positive regulation of protein binding
F	0032991	cellular_component	protein-containing complex
F	0035281	biological_process	pre-miRNA export from nucleus
F	0036126	cellular_component	sperm flagellum
F	0042307	biological_process	positive regulation of protein import into nucleus
F	0042470	cellular_component	melanosome
F	0042565	cellular_component	RNA nuclear export complex
F	0044877	molecular_function	protein-containing complex binding
F	0045296	molecular_function	cadherin binding
F	0045505	molecular_function	dynein intermediate chain binding
F	0046039	biological_process	GTP metabolic process
F	0046872	molecular_function	metal ion binding
F	0046982	molecular_function	protein heterodimerization activity
F	0051301	biological_process	cell division
F	0055037	cellular_component	recycling endosome
F	0061015	biological_process	snRNA import into nucleus
F	0061676	molecular_function	importin-alpha family protein binding
F	0070062	cellular_component	extracellular exosome
F	0070883	molecular_function	pre-miRNA binding
F	0071389	biological_process	cellular response to mineralocorticoid stimulus
F	0090543	cellular_component	Flemming body
F	1902570	biological_process	protein localization to nucleolus

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA B 361

Chain	Residue
B	SER41
B	GLU106
B	TRP107
B	ILE109

site_id	AC2
Number of Residues	28
Details	BINDING SITE FOR RESIDUE GTP C 217

Chain	Residue
C	THR24
C	THR25
C	GLU36
C	LYS37
C	LYS38
C	TYR39
C	ALA41
C	THR42
C	ALA67
C	GLY68
C	ASN122
C	LYS123
C	ASP125
C	ILE126
C	SER150
C	ALA151
C	LYS152
C	MG218
C	HOH221
C	HOH223
C	HOH378
C	HOH555
C	HOH897
C	GLY19
C	GLY20
C	THR21
C	GLY22
C	LYS23

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG C 218

Chain	Residue
C	THR24
C	THR42
C	ASP65
C	THR66
C	GTP217

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA E 361

Chain	Residue
E	ASP17
E	LEU18
E	SER20
E	GLU106
E	SER270

site_id	AC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL E 362

Chain	Residue
E	PRO351

site_id	AC6
Number of Residues	24
Details	BINDING SITE FOR RESIDUE GTP F 217

Chain	Residue
F	GLY19
F	GLY20
F	THR21
F	GLY22
F	LYS23
F	THR24
F	THR25
F	GLU36
F	LYS37
F	LYS38
F	TYR39
F	ALA41
F	THR42
F	ALA67
F	GLY68
F	ASN122
F	LYS123
F	ASP125
F	ILE126
F	SER150
F	ALA151
F	LYS152
F	MG218
F	HOH359

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG F 218

Chain	Residue
F	THR24
F	THR42
F	ASP65
F	THR66
F	GTP217

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:O14980

Chain	Residue	Details
A	SER391
A	SER1031
D	SER391
D	SER1031
E	LYS144
E	TRP276

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0007744\|PubMed:23806337

Chain	Residue	Details
A	LYS446
D	LYS446

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000250\|UniProtKB:Q80U96

Chain	Residue	Details
A	THR448
D	THR448

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:Q80U96

Chain	Residue	Details
A	SER450
D	SER450

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0000250\|UniProtKB:Q80U96

Chain	Residue	Details
A	TYR454
D	TYR454

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:O14980

Chain	Residue	Details
A	LYS693
D	LYS693

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: N-acetylalanine => ECO:0000269\|Ref.12, ECO:0007744\|PubMed:19413330, ECO:0007744\|PubMed:22223895, ECO:0007744\|PubMed:22814378

Chain	Residue	Details
C	ALA2
F	ALA2

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
C	THR24
F	THR24

site_id	SWS_FT_FI9
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000269\|PubMed:31075303

Chain	Residue	Details
C	LYS37
F	LYS37

site_id	SWS_FT_FI10
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
C	LYS60
C	LYS99
F	LYS60
F	LYS99

site_id	SWS_FT_FI11
Number of Residues	2
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
C	LYS71
F	LYS71

site_id	SWS_FT_FI12
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000269\|PubMed:29040603

Chain	Residue	Details
C	LYS134
F	LYS134

site_id	SWS_FT_FI13
Number of Residues	2
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250\|UniProtKB:P62827

Chain	Residue	Details
C	LYS159
F	LYS159

site_id	SWS_FT_FI14
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate

Chain	Residue	Details
C	LYS71
F	LYS71

site_id	SWS_FT_FI15
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744\|PubMed:28112733

Chain	Residue	Details
C	LYS152
F	LYS152

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
C	LEU69

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
F	LEU69

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
C	GLY20

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
F	GLY20

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)