Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3GJX

Crystal Structure of the Nuclear Export Complex CRM1-Snurportin1-RanGTP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000054	biological_process	ribosomal subunit export from nucleus
A	0000055	biological_process	ribosomal large subunit export from nucleus
A	0000056	biological_process	ribosomal small subunit export from nucleus
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0000776	cellular_component	kinetochore
A	0003723	molecular_function	RNA binding
A	0005049	molecular_function	nuclear export signal receptor activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005642	cellular_component	annulate lamellae
A	0005654	cellular_component	nucleoplasm
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006406	biological_process	mRNA export from nucleus
A	0006611	biological_process	protein export from nucleus
A	0006886	biological_process	intracellular protein transport
A	0006913	biological_process	nucleocytoplasmic transport
A	0009410	biological_process	response to xenobiotic stimulus
A	0010824	biological_process	regulation of centrosome duplication
A	0015030	cellular_component	Cajal body
A	0015031	biological_process	protein transport
A	0019904	molecular_function	protein domain specific binding
A	0031267	molecular_function	small GTPase binding
A	0031965	cellular_component	nuclear membrane
A	0032434	biological_process	regulation of proteasomal ubiquitin-dependent protein catabolic process
A	0032991	cellular_component	protein-containing complex
A	0034504	biological_process	protein localization to nucleus
A	0042176	biological_process	regulation of protein catabolic process
A	0042254	biological_process	ribosome biogenesis
A	0046825	biological_process	regulation of protein export from nucleus
A	0051028	biological_process	mRNA transport
A	0071401	biological_process	cellular response to triglyceride
A	0140297	molecular_function	DNA-binding transcription factor binding
A	1902075	biological_process	cellular response to salt
A	1990904	cellular_component	ribonucleoprotein complex
B	0000339	molecular_function	RNA cap binding
B	0003723	molecular_function	RNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005643	cellular_component	nuclear pore
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006404	biological_process	RNA import into nucleus
B	0006606	biological_process	protein import into nucleus
B	0007010	biological_process	cytoskeleton organization
B	0051259	biological_process	protein complex oligomerization
B	0051262	biological_process	protein tetramerization
B	0061015	biological_process	snRNA import into nucleus
B	0061608	molecular_function	nuclear import signal receptor activity
C	0000054	biological_process	ribosomal subunit export from nucleus
C	0000055	biological_process	ribosomal large subunit export from nucleus
C	0000056	biological_process	ribosomal small subunit export from nucleus
C	0000070	biological_process	mitotic sister chromatid segregation
C	0000166	molecular_function	nucleotide binding
C	0000278	biological_process	mitotic cell cycle
C	0000287	molecular_function	magnesium ion binding
C	0000785	cellular_component	chromatin
C	0001673	cellular_component	male germ cell nucleus
C	0002177	cellular_component	manchette
C	0003682	molecular_function	chromatin binding
C	0003723	molecular_function	RNA binding
C	0003924	molecular_function	GTPase activity
C	0003925	molecular_function	G protein activity
C	0005049	molecular_function	nuclear export signal receptor activity
C	0005515	molecular_function	protein binding
C	0005525	molecular_function	GTP binding
C	0005634	cellular_component	nucleus
C	0005635	cellular_component	nuclear envelope
C	0005643	cellular_component	nuclear pore
C	0005654	cellular_component	nucleoplasm
C	0005730	cellular_component	nucleolus
C	0005737	cellular_component	cytoplasm
C	0005814	cellular_component	centriole
C	0005829	cellular_component	cytosol
C	0006259	biological_process	DNA metabolic process
C	0006606	biological_process	protein import into nucleus
C	0006611	biological_process	protein export from nucleus
C	0006913	biological_process	nucleocytoplasmic transport
C	0007052	biological_process	mitotic spindle organization
C	0007286	biological_process	spermatid development
C	0015031	biological_process	protein transport
C	0016020	cellular_component	membrane
C	0016032	biological_process	viral process
C	0016787	molecular_function	hydrolase activity
C	0019003	molecular_function	GDP binding
C	0019904	molecular_function	protein domain specific binding
C	0021766	biological_process	hippocampus development
C	0030496	cellular_component	midbody
C	0032991	cellular_component	protein-containing complex
C	0035281	biological_process	pre-miRNA export from nucleus
C	0036126	cellular_component	sperm flagellum
C	0042307	biological_process	positive regulation of protein import into nucleus
C	0042470	cellular_component	melanosome
C	0042565	cellular_component	RNA nuclear export complex
C	0044877	molecular_function	protein-containing complex binding
C	0045296	molecular_function	cadherin binding
C	0045505	molecular_function	dynein intermediate chain binding
C	0046039	biological_process	GTP metabolic process
C	0046872	molecular_function	metal ion binding
C	0046982	molecular_function	protein heterodimerization activity
C	0051301	biological_process	cell division
C	0055037	cellular_component	recycling endosome
C	0061015	biological_process	snRNA import into nucleus
C	0061676	molecular_function	importin-alpha family protein binding
C	0070062	cellular_component	extracellular exosome
C	0070883	molecular_function	pre-miRNA binding
C	0071389	biological_process	cellular response to mineralocorticoid stimulus
C	0090543	cellular_component	Flemming body
C	1902570	biological_process	protein localization to nucleolus
D	0000054	biological_process	ribosomal subunit export from nucleus
D	0000055	biological_process	ribosomal large subunit export from nucleus
D	0000056	biological_process	ribosomal small subunit export from nucleus
D	0000122	biological_process	negative regulation of transcription by RNA polymerase II
D	0000776	cellular_component	kinetochore
D	0003723	molecular_function	RNA binding
D	0005049	molecular_function	nuclear export signal receptor activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005642	cellular_component	annulate lamellae
D	0005654	cellular_component	nucleoplasm
D	0005730	cellular_component	nucleolus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006406	biological_process	mRNA export from nucleus
D	0006611	biological_process	protein export from nucleus
D	0006886	biological_process	intracellular protein transport
D	0006913	biological_process	nucleocytoplasmic transport
D	0009410	biological_process	response to xenobiotic stimulus
D	0010824	biological_process	regulation of centrosome duplication
D	0015030	cellular_component	Cajal body
D	0015031	biological_process	protein transport
D	0019904	molecular_function	protein domain specific binding
D	0031267	molecular_function	small GTPase binding
D	0031965	cellular_component	nuclear membrane
D	0032434	biological_process	regulation of proteasomal ubiquitin-dependent protein catabolic process
D	0032991	cellular_component	protein-containing complex
D	0034504	biological_process	protein localization to nucleus
D	0042176	biological_process	regulation of protein catabolic process
D	0042254	biological_process	ribosome biogenesis
D	0046825	biological_process	regulation of protein export from nucleus
D	0051028	biological_process	mRNA transport
D	0071401	biological_process	cellular response to triglyceride
D	0140297	molecular_function	DNA-binding transcription factor binding
D	1902075	biological_process	cellular response to salt
D	1990904	cellular_component	ribonucleoprotein complex
E	0000339	molecular_function	RNA cap binding
E	0003723	molecular_function	RNA binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005643	cellular_component	nuclear pore
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006404	biological_process	RNA import into nucleus
E	0006606	biological_process	protein import into nucleus
E	0007010	biological_process	cytoskeleton organization
E	0051259	biological_process	protein complex oligomerization
E	0051262	biological_process	protein tetramerization
E	0061015	biological_process	snRNA import into nucleus
E	0061608	molecular_function	nuclear import signal receptor activity
F	0000054	biological_process	ribosomal subunit export from nucleus
F	0000055	biological_process	ribosomal large subunit export from nucleus
F	0000056	biological_process	ribosomal small subunit export from nucleus
F	0000070	biological_process	mitotic sister chromatid segregation
F	0000166	molecular_function	nucleotide binding
F	0000278	biological_process	mitotic cell cycle
F	0000287	molecular_function	magnesium ion binding
F	0000785	cellular_component	chromatin
F	0001673	cellular_component	male germ cell nucleus
F	0002177	cellular_component	manchette
F	0003682	molecular_function	chromatin binding
F	0003723	molecular_function	RNA binding
F	0003924	molecular_function	GTPase activity
F	0003925	molecular_function	G protein activity
F	0005049	molecular_function	nuclear export signal receptor activity
F	0005515	molecular_function	protein binding
F	0005525	molecular_function	GTP binding
F	0005634	cellular_component	nucleus
F	0005635	cellular_component	nuclear envelope
F	0005643	cellular_component	nuclear pore
F	0005654	cellular_component	nucleoplasm
F	0005730	cellular_component	nucleolus
F	0005737	cellular_component	cytoplasm
F	0005814	cellular_component	centriole
F	0005829	cellular_component	cytosol
F	0006259	biological_process	DNA metabolic process
F	0006606	biological_process	protein import into nucleus
F	0006611	biological_process	protein export from nucleus
F	0006913	biological_process	nucleocytoplasmic transport
F	0007052	biological_process	mitotic spindle organization
F	0007286	biological_process	spermatid development
F	0015031	biological_process	protein transport
F	0016020	cellular_component	membrane
F	0016032	biological_process	viral process
F	0016787	molecular_function	hydrolase activity
F	0019003	molecular_function	GDP binding
F	0019904	molecular_function	protein domain specific binding
F	0021766	biological_process	hippocampus development
F	0030496	cellular_component	midbody
F	0032991	cellular_component	protein-containing complex
F	0035281	biological_process	pre-miRNA export from nucleus
F	0036126	cellular_component	sperm flagellum
F	0042307	biological_process	positive regulation of protein import into nucleus
F	0042470	cellular_component	melanosome
F	0042565	cellular_component	RNA nuclear export complex
F	0044877	molecular_function	protein-containing complex binding
F	0045296	molecular_function	cadherin binding
F	0045505	molecular_function	dynein intermediate chain binding
F	0046039	biological_process	GTP metabolic process
F	0046872	molecular_function	metal ion binding
F	0046982	molecular_function	protein heterodimerization activity
F	0051301	biological_process	cell division
F	0055037	cellular_component	recycling endosome
F	0061015	biological_process	snRNA import into nucleus
F	0061676	molecular_function	importin-alpha family protein binding
F	0070062	cellular_component	extracellular exosome
F	0070883	molecular_function	pre-miRNA binding
F	0071389	biological_process	cellular response to mineralocorticoid stimulus
F	0090543	cellular_component	Flemming body
F	1902570	biological_process	protein localization to nucleolus

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA B 361

Chain	Residue
B	SER41
B	GLU106
B	TRP107
B	ILE109

site_id	AC2
Number of Residues	28
Details	BINDING SITE FOR RESIDUE GTP C 217

Chain	Residue
C	THR24
C	THR25
C	GLU36
C	LYS37
C	LYS38
C	TYR39
C	ALA41
C	THR42
C	ALA67
C	GLY68
C	ASN122
C	LYS123
C	ASP125
C	ILE126
C	SER150
C	ALA151
C	LYS152
C	MG218
C	HOH221
C	HOH223
C	HOH378
C	HOH555
C	HOH897
C	GLY19
C	GLY20
C	THR21
C	GLY22
C	LYS23

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG C 218

Chain	Residue
C	THR24
C	THR42
C	ASP65
C	THR66
C	GTP217

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA E 361

Chain	Residue
E	ASP17
E	LEU18
E	SER20
E	GLU106
E	SER270

site_id	AC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL E 362

Chain	Residue
E	PRO351

site_id	AC6
Number of Residues	24
Details	BINDING SITE FOR RESIDUE GTP F 217

Chain	Residue
F	GLY19
F	GLY20
F	THR21
F	GLY22
F	LYS23
F	THR24
F	THR25
F	GLU36
F	LYS37
F	LYS38
F	TYR39
F	ALA41
F	THR42
F	ALA67
F	GLY68
F	ASN122
F	LYS123
F	ASP125
F	ILE126
F	SER150
F	ALA151
F	LYS152
F	MG218
F	HOH359

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG F 218

Chain	Residue
F	THR24
F	THR42
F	ASP65
F	THR66
F	GTP217

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Region: {"description":"Interaction with m3G-cap structure","evidences":[{"source":"PubMed","id":"15920472","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1XK5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	30
Details	Compositional bias: {"description":"Polar residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	6
Details	Site: {"description":"Interaction with m3G-cap structure","evidences":[{"source":"PubMed","id":"15920472","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1XK5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	16
Details	Region: {"description":"Switch-I","evidences":[{"source":"PROSITE-ProRule","id":"PRU00752","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	32
Details	Region: {"description":"Switch-II","evidences":[{"source":"PROSITE-ProRule","id":"PRU00752","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10078529","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10353245","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10367892","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11832950","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18611384","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19389996","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19505478","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24449914","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24915079","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26272610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26349033","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28282025","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7885480","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1IBR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K5G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RRP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CH5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NBY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NBZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NC0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NC1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZJY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4C0Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OL0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CIQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CIT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CIW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CLQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DH9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DHA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DHF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DI9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DIF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DIS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DLQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10078529","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10353245","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10367892","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11832950","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19389996","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24449914","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24915079","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26272610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26349033","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28282025","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7885480","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1IBR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K5D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RRP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NBY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NBZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NC0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NC1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZJY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4C0Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OL0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CLL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CLQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DH9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DHA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DHF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DI9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DIF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DIS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DLQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JLJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10078529","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10353245","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10367892","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11832950","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18611384","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19389996","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19505478","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24449914","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24915079","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26272610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26349033","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28282025","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7885480","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1IBR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K5D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RRP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NBY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NBZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NC0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NC1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZJY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4C0Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OL0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DH9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DHA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DHF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DI9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DIF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DIS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DLQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JLJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10078529","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10353245","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10367892","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11832950","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18611384","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19389996","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19505478","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24449914","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24915079","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26272610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26349033","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28282025","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7885480","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1IBR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K5D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RRP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CH5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NBY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NBZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NC0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NC1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZJY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4C0Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OL0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CIQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CIT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CIW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CJ2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CLL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DH9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DHA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DHF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DI9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DIF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DIS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DLQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JLJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10078529","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10353245","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10367892","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11832950","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18611384","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19389996","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19505478","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24449914","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24915079","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26272610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26349033","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28282025","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7885480","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1K5G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CH5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJ8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GJX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NBY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NBZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NC0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NC1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZJY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4C0Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OL0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CIQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CIT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CIW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CJ2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CLL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CLQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DH9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DHA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DHF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DI9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DIF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DIS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DLQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JLJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UWW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	2
Details	Site: {"description":"Essential for GTP hydrolysis","evidences":[{"source":"PubMed","id":"18591255","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26272610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8636225","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"31075303","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"29040603","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P62827","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate"}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	46
Details	Repeat: {"description":"HEAT 1"}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	72
Details	Repeat: {"description":"HEAT 2"}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	236
Details	Repeat: {"description":"HEAT 3"}

Chain

Residue

Details

site_id	SWS_FT_FI25
Number of Residues	76
Details	Repeat: {"description":"HEAT 4"}

Chain

Residue

Details

site_id	SWS_FT_FI26
Number of Residues	74
Details	Repeat: {"description":"HEAT 5"}

Chain

Residue

Details

site_id	SWS_FT_FI27
Number of Residues	74
Details	Repeat: {"description":"HEAT 6"}

Chain

Residue

Details

site_id	SWS_FT_FI28
Number of Residues	76
Details	Repeat: {"description":"HEAT 7"}

Chain

Residue

Details

site_id	SWS_FT_FI29
Number of Residues	62
Details	Repeat: {"description":"HEAT 8"}

Chain

Residue

Details

site_id	SWS_FT_FI30
Number of Residues	74
Details	Repeat: {"description":"HEAT 9"}

Chain

Residue

Details

site_id	SWS_FT_FI31
Number of Residues	74
Details	Repeat: {"description":"HEAT 10"}

Chain

Residue

Details

site_id	SWS_FT_FI32
Number of Residues	246
Details	Region: {"description":"Necessary for interaction with Ran and nuclear export complex formation","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI33
Number of Residues	140
Details	Region: {"description":"Necessary for interaction with RANBP3","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI34
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"O14980","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI35
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"23806337","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI36
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q80U96","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI37
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q80U96","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI38
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q80U96","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI39
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"O14980","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
C	LEU69

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
F	LEU69

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
C	GLY20

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
F	GLY20

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)