3GG5
Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Thymidylate synthase | polymer | 313 | 35827.0 | 4 | UniProt (P04818) Pfam (PF00303) In PDB | Homo sapiens (Human) | TSase, TS |
| 2 | A, C | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 3 | B, D | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
| 4 | water | water | 18.0 | 23 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 313 (UniProt: P04818)
| PDB | External Database | Details |
|---|---|---|
| Tyr 3 | Val 3 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 143307.9 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 382.1 | |
| All* | Total formula weight | 143690.0 |
