3G65

Crystal Structure of the Human Rad9-Rad1-Hus1 DNA Damage Checkpoint Complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Cell cycle checkpoint control protein RAD9A	polymer	296	32452.3	1	UniProt (Q99638) Pfam (PF04139) In PDB	Homo sapiens (human)	hRAD9, DNA repair exonuclease rad9 homolog A
2	B	Cell cycle checkpoint protein RAD1	polymer	282	31854.2	1	UniProt (O60671) Pfam (PF02144) In PDB	Homo sapiens (human)	hRAD1, DNA repair exonuclease rad1 homolog, Rad1-like DNA damage checkpoint protein
3	C	Checkpoint protein HUS1	polymer	280	31731.9	1	UniProt (O60921) Pfam (PF04005) In PDB	Homo sapiens (human)	hHUS1
4		water	water		18.0	82	Chemie (HOH)

Sequence modifications

A: 1 - 270 (UniProt: Q99638)

PDB	External Database	Details
Gly 271	-	expression tag
Thr 272	-	expression tag
Thr 273	-	expression tag
Ser 274	-	expression tag
Thr 275	-	expression tag
Ser 276	-	expression tag
Leu 277	-	expression tag
Glu 278	-	expression tag
Val 279	-	expression tag
Leu 280	-	expression tag
Phe 281	-	expression tag
Gln 282	-	expression tag
Gly 283	-	expression tag
Pro 284	-	expression tag
Leu 285	-	expression tag
Ser 286	-	expression tag
Gly 287	-	expression tag
Ser 288	-	expression tag
Gly 289	-	expression tag
Gly 290	-	expression tag
His 291	-	expression tag
His 292	-	expression tag
His 293	-	expression tag
His 294	-	expression tag
His 295	-	expression tag
His 296	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	96038.3
All*	Total formula weight	96038.3

*Water molecules are not included.