3G0F
KIT kinase domain mutant D816H in complex with sunitinib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Mast/stem cell growth factor receptor | polymer | 336 | 38240.2 | 2 | UniProt (P10721) Pfam (PF07714) In PDB | Homo sapiens (human) | SCFR, Proto-oncogene tyrosine-protein kinase Kit, c-kit |
| 2 | A, B | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carbo xamide | non-polymer | 398.5 | 2 | Chemie (B49) | |||
| 3 | A | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | water | water | 18.0 | 15 | Chemie (HOH) |
Sequence modifications
A, B: 544 - 693 (UniProt: P10721)
A, B: 754 - 935 (UniProt: P10721)
| PDB | External Database | Details |
|---|---|---|
| Gly 542 | - | expression tag |
| Pro 543 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Thr 694 | - | SEE REMARK 999 |
| Ser 753 | - | SEE REMARK 999 |
| His 816 | Asp 816 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 76480.5 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 893.0 | |
| All* | Total formula weight | 77373.5 |
