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3G0F

KIT kinase domain mutant D816H in complex with sunitinib

Functional Information from GO Data
ChainGOidnamespacecontents
A0004672molecular_functionprotein kinase activity
A0004713molecular_functionprotein tyrosine kinase activity
A0004714molecular_functiontransmembrane receptor protein tyrosine kinase activity
A0005524molecular_functionATP binding
A0006468biological_processprotein phosphorylation
A0007169biological_processcell surface receptor protein tyrosine kinase signaling pathway
B0004672molecular_functionprotein kinase activity
B0004713molecular_functionprotein tyrosine kinase activity
B0004714molecular_functiontransmembrane receptor protein tyrosine kinase activity
B0005524molecular_functionATP binding
B0006468biological_processprotein phosphorylation
B0007169biological_processcell surface receptor protein tyrosine kinase signaling pathway
Functional Information from PDB Data
site_idAC1
Number of Residues9
DetailsBINDING SITE FOR RESIDUE B49 A9001
ChainResidue
AVAL603
AALA621
ATHR670
AGLU671
ATYR672
ACYS673
ACYS674
ALEU799
ACYS809

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 A 1
ChainResidue
AHIS630
ALEU631
AARG634
BLYS826
BGLY827

site_idAC3
Number of Residues12
DetailsBINDING SITE FOR RESIDUE B49 B9001
ChainResidue
BLEU595
BVAL603
BALA621
BTHR670
BGLU671
BTYR672
BCYS673
BGLY676
BLEU799
BCYS809
BASP810
BPHE811

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues29
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGAGAFGKVVeAtaygliksdaamt.....VAVK
ChainResidueDetails
ALEU595-LYS623

site_idPS00109
Number of Residues13
DetailsPROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. CIHrDLAARNILL
ChainResidueDetails
ACYS788-LEU800

site_idPS00240
Number of Residues14
DetailsRECEPTOR_TYR_KIN_III Receptor tyrosine kinase class III signature. GnHmNIVNLLGACT
ChainResidueDetails
AGLY648-THR661

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028
ChainResidueDetails
AASP792
BASP792

site_idSWS_FT_FI2
Number of Residues14
DetailsBINDING:
ChainResidueDetails
ATYR568
BLYS623
BGLU671
BARG796
BASN797
BASP810
AGLY596
ALYS623
AGLU671
AARG796
AASN797
AASP810
BTYR568
BGLY596

site_idSWS_FT_FI3
Number of Residues6
DetailsMOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000305|PubMed:20147452
ChainResidueDetails
ATYR547
ATYR553
ACYS788
BTYR547
BTYR553
BCYS788

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:12824176, ECO:0000269|PubMed:19265199, ECO:0000269|PubMed:21030588, ECO:0000269|PubMed:9038210
ChainResidueDetails
ATYR568
BTYR568

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:12824176, ECO:0000269|PubMed:9038210
ChainResidueDetails
ATYR570
BTYR570

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:10377264, ECO:0000269|PubMed:19265199, ECO:0000269|PubMed:20147452
ChainResidueDetails
AGLU761
BGLU761

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:19265199, ECO:0000269|PubMed:20147452, ECO:0000269|PubMed:9038210
ChainResidueDetails
AGLY779
BGLY779

site_idSWS_FT_FI8
Number of Residues4
DetailsMOD_RES: Phosphoserine; by PKC/PRKCA => ECO:0000269|PubMed:7539802
ChainResidueDetails
ALEU799
AARG804
BLEU799
BARG804

site_idSWS_FT_FI9
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:7539802
ChainResidueDetails
ASER821
BSER821

site_idSWS_FT_FI10
Number of Residues2
DetailsMOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:20147452
ChainResidueDetails
ATYR823
BTYR823

site_idSWS_FT_FI11
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:12878163
ChainResidueDetails
ASER891
BSER891

site_idSWS_FT_FI12
Number of Residues2
DetailsMOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:12878163, ECO:0000269|PubMed:20147452
ChainResidueDetails
ATYR900
BTYR900

Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
AASP792
AARG796

site_idCSA2
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
BASP792
BARG796

site_idCSA3
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
AASP792
AALA794

site_idCSA4
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
BASP792
BALA794

site_idCSA5
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
AASN797
AASP792
AALA794

site_idCSA6
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
BASN797
BASP792
BALA794

221716

PDB entries from 2024-06-26

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