3FXW

High resolution crystal structure of mitogen-activated protein kinase-activated protein kinase 3/inhibitor 2 complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	MAP kinase-activated protein kinase 3	polymer	336	38575.0	1	UniProt (Q16644) Pfam (PF00069)	Homo sapiens (human)	MK3, MAPK-activated protein kinase 3, MAPKAP kinase 3, MAPKAPK-3, Chromosome 3p kinase, 3pK
2	B (A)	2-[2-(2-FLUOROPHENYL)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE	non-polymer		307.3	1	Chemie (F10)
3	C (A)	water	water		18.0	106	Chemie (HOH)

Sequence modifications

A: 33 - 349 (UniProt: Q16644)

PDB	External Database	Details
Met 14	-	expression tag
Ala 15	-	expression tag
His 16	-	expression tag
His 17	-	expression tag
His 18	-	expression tag
His 19	-	expression tag
His 20	-	expression tag
His 21	-	expression tag
Ser 22	-	expression tag
Ser 23	-	expression tag
Gly 24	-	expression tag
Leu 25	-	expression tag
Glu 26	-	expression tag
Val 27	-	expression tag
Leu 28	-	expression tag
Phe 29	-	expression tag
Gln 30	-	expression tag
Gly 31	-	expression tag
Pro 32	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	38575.0
Non-Polymers*	Number of molecules	1
	Total formula weight	307.3
All*	Total formula weight	38882.3

*Water molecules are not included.