3FXI
Crystal structure of the human TLR4-human MD-2-E.coli LPS Ra complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Toll-like receptor 4 | polymer | 605 | 68838.3 | 2 | UniProt (O00206) Pfam (PF13855) Pfam (PF12799) Pfam (PF13516) | Homo sapiens (human) | TLR4, hToll |
| 2 | C, D (C, D) | Lymphocyte antigen 96 | polymer | 142 | 16385.9 | 2 | UniProt (Q9Y6Y9) Pfam (PF02221) | Homo sapiens (human) | MD-2, Protein MD-2, ESOP-1 |
| 3 | E (E) | L-glycero-alpha-D-manno-heptopyranose-(1-7)-L-glycero-alpha-D-manno-heptopyranose-(1-3)-L-glycero-alpha-D-manno-heptopyranose-(1-5)-[3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid-(2-4)]3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid-(2-6)-2-amino-2-deoxy-alpha-D-glucopyranose-(1-6)-2-amino-2-deoxy-alpha-D-glucopyranose | branched | 1357.2 | 1 | In PDB GlyTouCan (G75876QI) | |||
| 4 | F, G, I, J (F, G, I, J) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 4 | In PDB GlyTouCan (G42666HT) | |||
| 5 | H (H) | L-glycero-alpha-D-manno-heptopyranose-(1-7)-L-glycero-alpha-D-manno-heptopyranose-(1-3)-L-glycero-alpha-D-manno-heptopyranose-(1-5)-[3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid-(2-4)]3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid-(2-6)-2-amino-2-deoxy-beta-D-glucopyranose-(1-6)-2-amino-2-deoxy-alpha-D-glucopyranose | branched | 1357.2 | 1 | In PDB GlyTouCan (G02042LC) | |||
| 6 | AA, BA, K, L, M... (B, A) | 3-HYDROXY-TETRADECANOIC ACID | non-polymer | 244.4 | 8 | Chemie (FTT) | |||
| 7 | CA, O (B, A) | LAURIC ACID | non-polymer | 200.3 | 2 | Chemie (DAO) | |||
| 8 | DA, P (B, A) | MYRISTIC ACID | non-polymer | 228.4 | 2 | Chemie (MYR) | |||
| 9 | EA, FA, GA, HA, Q... (B, A) | PHOSPHATE ION | non-polymer | 95.0 | 8 | Chemie (PO4) | |||
| 10 | IA, JA, KA, MA, NA... (B, C, D, A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 8 | Chemie (NAG) | |||
| 11 | LA, X (B, A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 12 | OA, PA (A, B) | water | water | 18.0 | 2 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 170448.5 | |
| Branched | Number of molecules | 6 |
| Total formula weight | 4412.0 | |
| Non-Polymers* | Number of molecules | 30 |
| Total formula weight | 5390.4 | |
| All* | Total formula weight | 180250.9 |
