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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

3FXI

Crystal structure of the human TLR4-human MD-2-E.coli LPS Ra complex

Functional Information from GO Data
ChainGOidnamespacecontents
C0001530molecular_functionlipopolysaccharide binding
C0001875molecular_functionlipopolysaccharide immune receptor activity
C0002221biological_processpattern recognition receptor signaling pathway
C0002224biological_processtoll-like receptor signaling pathway
C0002376biological_processimmune system process
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005886cellular_componentplasma membrane
C0006954biological_processinflammatory response
C0006968biological_processcellular defense response
C0007166biological_processcell surface receptor signaling pathway
C0010008cellular_componentendosome membrane
C0015026molecular_functioncoreceptor activity
C0031663biological_processlipopolysaccharide-mediated signaling pathway
C0031666biological_processpositive regulation of lipopolysaccharide-mediated signaling pathway
C0032496biological_processresponse to lipopolysaccharide
C0032497biological_processdetection of lipopolysaccharide
C0032760biological_processpositive regulation of tumor necrosis factor production
C0034142biological_processtoll-like receptor 4 signaling pathway
C0035662molecular_functionToll-like receptor 4 binding
C0045087biological_processinnate immune response
C0046696cellular_componentlipopolysaccharide receptor complex
C0071222biological_processcellular response to lipopolysaccharide
D0001530molecular_functionlipopolysaccharide binding
D0001875molecular_functionlipopolysaccharide immune receptor activity
D0002221biological_processpattern recognition receptor signaling pathway
D0002224biological_processtoll-like receptor signaling pathway
D0002376biological_processimmune system process
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005886cellular_componentplasma membrane
D0006954biological_processinflammatory response
D0006968biological_processcellular defense response
D0007166biological_processcell surface receptor signaling pathway
D0010008cellular_componentendosome membrane
D0015026molecular_functioncoreceptor activity
D0031663biological_processlipopolysaccharide-mediated signaling pathway
D0031666biological_processpositive regulation of lipopolysaccharide-mediated signaling pathway
D0032496biological_processresponse to lipopolysaccharide
D0032497biological_processdetection of lipopolysaccharide
D0032760biological_processpositive regulation of tumor necrosis factor production
D0034142biological_processtoll-like receptor 4 signaling pathway
D0035662molecular_functionToll-like receptor 4 binding
D0045087biological_processinnate immune response
D0046696cellular_componentlipopolysaccharide receptor complex
D0071222biological_processcellular response to lipopolysaccharide
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues42
DetailsRepeat: {"description":"LRR 1"}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues42
DetailsRepeat: {"description":"LRR 2"}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues42
DetailsRepeat: {"description":"LRR 3"}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues42
DetailsRepeat: {"description":"LRR 4"}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues42
DetailsRepeat: {"description":"LRR 5"}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues46
DetailsRepeat: {"description":"LRR 6"}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues40
DetailsRepeat: {"description":"LRR 7"}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues40
DetailsRepeat: {"description":"LRR 8"}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues40
DetailsRepeat: {"description":"LRR 9"}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues42
DetailsRepeat: {"description":"LRR 10"}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues40
DetailsRepeat: {"description":"LRR 11"}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues44
DetailsRepeat: {"description":"LRR 12"}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues42
DetailsRepeat: {"description":"LRR 13"}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues16
DetailsRepeat: {"description":"LRR 14"}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues46
DetailsRepeat: {"description":"LRR 15"}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues42
DetailsRepeat: {"description":"LRR 16"}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues42
DetailsRepeat: {"description":"LRR 17"}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues40
DetailsRepeat: {"description":"LRR 18"}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11706042","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17803912","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22363519","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11706042","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17803912","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19252480","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22363519","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11706042","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17803912","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19252480","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues6
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11706042","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11706042","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19252480","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11706042","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19252480","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38670073","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues8
DetailsRegion: {"description":"Interaction with lipopolysaccharide","evidences":[{"source":"PubMed","id":"17569869","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17803912","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2E56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E59","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4G8A","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI26
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"17569869","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2E56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2E59","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

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