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3FXI

Crystal structure of the human TLR4-human MD-2-E.coli LPS Ra complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0002224biological_processtoll-like receptor signaling pathway
A0004888molecular_functiontransmembrane signaling receptor activity
A0006955biological_processimmune response
A0016020cellular_componentmembrane
B0002224biological_processtoll-like receptor signaling pathway
B0004888molecular_functiontransmembrane signaling receptor activity
B0006955biological_processimmune response
B0016020cellular_componentmembrane
C0001530molecular_functionlipopolysaccharide binding
C0001875molecular_functionlipopolysaccharide immune receptor activity
C0002224biological_processtoll-like receptor signaling pathway
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005886cellular_componentplasma membrane
C0006954biological_processinflammatory response
C0006968biological_processcellular defense response
C0007166biological_processcell surface receptor signaling pathway
C0010008cellular_componentendosome membrane
C0015026molecular_functioncoreceptor activity
C0031663biological_processlipopolysaccharide-mediated signaling pathway
C0031666biological_processpositive regulation of lipopolysaccharide-mediated signaling pathway
C0032496biological_processresponse to lipopolysaccharide
C0032497biological_processdetection of lipopolysaccharide
C0032760biological_processpositive regulation of tumor necrosis factor production
C0034142biological_processtoll-like receptor 4 signaling pathway
C0035662molecular_functionToll-like receptor 4 binding
C0043235cellular_componentreceptor complex
C0045087biological_processinnate immune response
C0046696cellular_componentlipopolysaccharide receptor complex
C0071222biological_processcellular response to lipopolysaccharide
D0001530molecular_functionlipopolysaccharide binding
D0001875molecular_functionlipopolysaccharide immune receptor activity
D0002224biological_processtoll-like receptor signaling pathway
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005886cellular_componentplasma membrane
D0006954biological_processinflammatory response
D0006968biological_processcellular defense response
D0007166biological_processcell surface receptor signaling pathway
D0010008cellular_componentendosome membrane
D0015026molecular_functioncoreceptor activity
D0031663biological_processlipopolysaccharide-mediated signaling pathway
D0031666biological_processpositive regulation of lipopolysaccharide-mediated signaling pathway
D0032496biological_processresponse to lipopolysaccharide
D0032497biological_processdetection of lipopolysaccharide
D0032760biological_processpositive regulation of tumor necrosis factor production
D0034142biological_processtoll-like receptor 4 signaling pathway
D0035662molecular_functionToll-like receptor 4 binding
D0043235cellular_componentreceptor complex
D0045087biological_processinnate immune response
D0046696cellular_componentlipopolysaccharide receptor complex
D0071222biological_processcellular response to lipopolysaccharide
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17569869, ECO:0007744|PDB:2E56, ECO:0007744|PDB:2E59
ChainResidueDetails
CASN26
CASN114
DASN26
DASN114

site_idSWS_FT_FI2
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11706042, ECO:0000269|PubMed:17803912, ECO:0000269|PubMed:19252480, ECO:0000269|PubMed:22363519
ChainResidueDetails
AASN173
BASN173

site_idSWS_FT_FI3
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11706042, ECO:0000269|PubMed:17803912, ECO:0000269|PubMed:19252480
ChainResidueDetails
AASN205
BASN205

site_idSWS_FT_FI4
Number of Residues6
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11706042
ChainResidueDetails
AASN282
AASN309
AASN624
BASN282
BASN309
BASN624

site_idSWS_FT_FI5
Number of Residues6
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11706042, ECO:0000269|PubMed:19252480
ChainResidueDetails
AASN497
AASN526
AASN575
BASN497
BASN526
BASN575

site_idSWS_FT_FI6
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN630
BASN630

226707

PDB entries from 2024-10-30

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