3FGM

Crystal structure of L44F/C83T/C117V/F132W mutant of Human acidic fibroblast growth factor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Heparin-binding growth factor 1	polymer	146	16753.7	2	UniProt (P05230) Pfam (PF00167) In PDB	Homo sapiens (human)	HBGF-1, Acidic fibroblast growth factor, aFGF, Beta-endothelial cell growth factor, ECGF-beta
2	A	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
3	A, B	FORMIC ACID	non-polymer		46.0	3	Chemie (FMT)
4		water	water		18.0	224	Chemie (HOH)

Sequence modifications

A, B: 1 - 140 (UniProt: P05230)

PDB	External Database	Details
His 1	-	expression tag
His 1	-	expression tag
His 1	-	expression tag
His 1	-	expression tag
His 1	-	expression tag
His 1	-	expression tag
Phe 44	Leu 59	engineered mutation
Thr 83	Cys 98	engineered mutation
Val 117	Cys 132	engineered mutation
Trp 132	Phe 147	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	33507.5
Non-Polymers*	Number of molecules	4
	Total formula weight	234.1
All*	Total formula weight	33741.6

*Water molecules are not included.