3FE1

Crystal structure of the human 70kDa heat shock protein 6 (Hsp70B') ATPase domain in complex with ADP and inorganic phosphate

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C (A, B, C)	Heat shock 70 kDa protein 6	polymer	403	44448.1	3	UniProt (P17066) Pfam (PF00012)	Homo sapiens (human)	HSP70B', Heat shock 70 kDa protein B'
2	D, G, L (A, B, C)	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	3	Chemie (ADP)
3	E, H, M (A, B, C)	PHOSPHATE ION	non-polymer		95.0	3	Chemie (PO4)
4	F, I, N (A, B, C)	MAGNESIUM ION	non-polymer		24.3	3	Chemie (MG)
5	J (B)	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
6	K (B)	TRIETHYLENE GLYCOL	non-polymer		150.2	1	Chemie (PGE)
7	O, P, Q (A, B, C)	water	water		18.0	333	Chemie (HOH)

Sequence modifications

A, B, C: 6 - 385 (UniProt: P17066)

PDB	External Database	Details
Met -17	-	initiating methionine
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
Ser -10	-	expression tag
Ser -9	-	expression tag
Gly -8	-	expression tag
Val -7	-	expression tag
Asp -6	-	expression tag
Leu -5	-	expression tag
Gly -4	-	expression tag
Thr -3	-	expression tag
Glu -2	-	expression tag
Asn -1	-	expression tag
Leu 0	-	expression tag
Tyr 1	-	expression tag
Phe 2	-	expression tag
Gln 3	-	expression tag
Ser 4	-	expression tag
Met 5	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	133344.2
Non-Polymers*	Number of molecules	11
	Total formula weight	1825.1
All*	Total formula weight	135169.3

*Water molecules are not included.