3FCZ
Adaptive protein evolution grants organismal fitness by improving catalysis and flexibility
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Beta-lactamase 2 | polymer | 222 | 24371.8 | 2 | UniProt (P04190) Pfam (PF00753) | Bacillus cereus | Beta-lactamase II, Penicillinase, Cephalosporinase |
| 2 | C, D, E, F (A, B) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 3 | G, H (A, B) | water | water | 18.0 | 42 | Chemie (HOH) |
Sequence modifications
A, B: 32 - 281 (UniProt: P04190)
| PDB | External Database | Details |
|---|---|---|
| Ser 70 | Asn 72 | engineered mutation |
| Ala 112 | Val 112 | engineered mutation |
| Ser 250 | Leu 227 | engineered mutation |
| Ser 262 | Gly 239 | engineered mutation |
| Leu 282 | - | expression tag |
| Leu 283 | - | expression tag |
| Leu 284 | - | expression tag |
| His 285 | - | expression tag |
| Thr 286 | - | expression tag |
| Leu 287 | - | expression tag |
| Asp 288 | - | expression tag |
| Leu 289 | - | expression tag |
| Leu 290 | - | expression tag |
| Lys 291 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 48743.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 261.6 | |
| All* | Total formula weight | 49005.2 |
