3F9Z
Structural Insights into Lysine Multiple Methylation by SET Domain Methyltransferases, SET8-Y245F / H4-Lys20 / AdoHcy
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Histone-lysine N-methyltransferase SETD8 | polymer | 166 | 18774.3 | 4 | UniProt (Q9NQR1) Pfam (PF00856) | Homo sapiens | H4-K20-HMTase SETD8, SET domain-containing protein 8, PR/SET domain-containing protein 07, PR/SET07, PR-Set7, Lysine N-methyltransferase 5A |
| 2 | E, F, G, H (E, F, G, H) | Histone H4 | polymer | 10 | 1284.6 | 4 | UniProt (P62805) | ||
| 3 | I, J, K, L (A, B, C, D) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 4 | Chemie (SAH) | |||
| 4 | M, N, O, P, Q... (A, B, C, D, E...) | water | water | 18.0 | 589 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 191 - 352 (UniProt: Q9NQR1)
| PDB | External Database | Details |
|---|---|---|
| Gly 187 | - | expression tag |
| Ala 188 | - | expression tag |
| Met 189 | - | expression tag |
| Gly 190 | - | expression tag |
| Phe 245 | Tyr 286 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 80235.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1537.6 | |
| All* | Total formula weight | 81772.9 |
