3F9W
Structural Insights into Lysine Multiple Methylation by SET Domain Methyltransferases, SET8-Y334F / H4-Lys20 / AdoHcy
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Histone-lysine N-methyltransferase SETD8 | polymer | 166 | 18774.3 | 4 | UniProt (Q9NQR1) Pfam (PF00856) | Homo sapiens | H4-K20-HMTase SETD8, SET domain-containing protein 8, PR/SET domain-containing protein 07, PR/SET07, PR-Set7, Lysine N-methyltransferase 5A |
| 2 | E, F, G, H (E, F, G, H) | Histone H4 | polymer | 10 | 1284.6 | 4 | UniProt (P62805) | ||
| 3 | I, J, K, L (A, B, C, D) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 4 | Chemie (SAH) PubChem (16760024) PubChem (25210495) PubChem (177678424) PubChem (21125603) PubChem (25203782) PubChem (52224400) PubChem (44361184) PubChem (46936206) PubChem (50989525) PubChem (51380914) PubChem (6419189) PubChem (52224398) PubChem (57544532) PubChem (164157219) PubChem (59046843) PubChem (59170628) PubChem (59576228) PubChem (66805708) PubChem (70689219) PubChem (70702054) PubChem (70832431) PubChem (118374891) PubChem (118560068) PubChem (193) PubChem (13792) PubChem (189149) PubChem (439155) PubChem (5284331) PubChem (126969526) PubChem (71170554) PubChem (129105892) PubChem (13231890) PubChem (143518505) PubChem (154578335) PubChem (163054214) PubChem (163335525) | |||
| 4 | M, N, O, P, Q... (A, B, C, D, E...) | water | water | 18.0 | 1022 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 191 - 352 (UniProt: Q9NQR1)
| PDB | External Database | Details |
|---|---|---|
| Gly 187 | - | expression tag |
| Ala 188 | - | expression tag |
| Met 189 | - | expression tag |
| Gly 190 | - | expression tag |
| Phe 334 | Tyr 375 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 80235.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1537.6 | |
| All* | Total formula weight | 81772.9 |
