3F9W
Structural Insights into Lysine Multiple Methylation by SET Domain Methyltransferases, SET8-Y334F / H4-Lys20 / AdoHcy
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE SAH A 801 |
| Chain | Residue |
| A | HOH100 |
| A | ARG295 |
| A | LEU296 |
| A | ASN298 |
| A | HIS299 |
| A | TYR336 |
| A | TRP349 |
| A | HOH364 |
| A | HOH387 |
| A | HOH432 |
| F | HIS18 |
| A | HOH108 |
| F | LYS20 |
| A | HOH148 |
| A | HOH154 |
| A | GLY225 |
| A | LYS226 |
| A | ARG228 |
| A | CYS270 |
| A | TYR271 |
| site_id | AC2 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE SAH B 801 |
| Chain | Residue |
| B | HOH76 |
| B | GLY225 |
| B | LYS226 |
| B | ARG228 |
| B | CYS270 |
| B | TYR271 |
| B | ARG295 |
| B | LEU296 |
| B | ASN298 |
| B | HIS299 |
| B | TYR336 |
| B | TRP349 |
| B | HOH364 |
| B | HOH371 |
| B | HOH382 |
| B | HOH389 |
| E | HIS18 |
| E | LYS20 |
| site_id | AC3 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE SAH C 801 |
| Chain | Residue |
| C | HOH149 |
| C | HOH171 |
| C | GLY225 |
| C | LYS226 |
| C | ARG228 |
| C | CYS270 |
| C | TYR271 |
| C | ARG295 |
| C | LEU296 |
| C | ASN298 |
| C | HIS299 |
| C | TYR336 |
| C | TRP349 |
| C | HOH377 |
| C | HOH378 |
| C | HOH408 |
| C | HOH412 |
| G | HIS18 |
| G | LYS20 |
| site_id | AC4 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE SAH D 801 |
| Chain | Residue |
| B | HOH26 |
| D | HOH47 |
| D | HOH55 |
| D | GLY225 |
| D | LYS226 |
| D | ARG228 |
| D | CYS270 |
| D | TYR271 |
| D | ARG295 |
| D | LEU296 |
| D | ASN298 |
| D | HIS299 |
| D | TYR336 |
| D | TRP349 |
| D | HOH380 |
| D | HOH413 |
| D | HOH576 |
| E | ARG23 |
| H | HIS18 |
| H | LYS20 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 484 |
| Details | Domain: {"description":"SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00190","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | DNA binding: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-propionyllysine; alternate","evidences":[{"source":"PubMed","id":"17267393","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"12086618","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15964846","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17967882","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27338793","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
