3EXF
Crystal structure of the pyruvate dehydrogenase (E1p) component of human pyruvate dehydrogenase complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C, E, G | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | polymer | 382 | 42552.5 | 4 | UniProt (P08559) Pfam (PF00676) In PDB | Homo sapiens (human) | pyruvate dehydrogenase (E1p) alpha subunit; PDHE1-A type I |
2 | B, D, F, H | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | polymer | 329 | 35941.3 | 4 | UniProt (P11177) Pfam (PF02779) Pfam (PF02780) In PDB | Homo sapiens (human) | pyruvate dehydrogenase (E1p) beta subunit; PDHE1-B |
3 | A, C, E, G | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
4 | A, C, E, G | THIAMINE DIPHOSPHATE | non-polymer | 425.3 | 4 | Chemie (TPP) | |||
5 | B, D, F, H | POTASSIUM ION | non-polymer | 39.1 | 4 | Chemie (K) | |||
6 | water | water | 18.0 | 9 | Chemie (HOH) |
Sequence modifications
A, C, E, G: 1 - 361 (UniProt: P08559)
PDB | External Database | Details |
---|---|---|
Met -20 | - | expression tag |
Gly -19 | - | expression tag |
Ser -18 | - | expression tag |
Ser -17 | - | expression tag |
His -16 | - | expression tag |
His -15 | - | expression tag |
His -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
Ser -10 | - | expression tag |
Ser -9 | - | expression tag |
Gly -8 | - | expression tag |
Leu -7 | - | expression tag |
Val -6 | - | expression tag |
Pro -5 | - | expression tag |
Arg -4 | - | expression tag |
Gly -3 | - | expression tag |
Ser -2 | - | expression tag |
His -1 | - | expression tag |
Met 0 | - | expression tag |
Ala 203 | Ser 232 | engineered mutation |
Ala 271 | Ser 300 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 313975.3 | |
Non-Polymers* | Number of molecules | 12 |
Total formula weight | 1954.9 | |
All* | Total formula weight | 315930.2 |